High-dose ascorbic acid prophylaxis in workers occupationally exposed to halogenated ethers

• Published in: Journal of hygiene, epidemiology, microbiology, and immunology Vol. 27; no. 3; p. 305
• Main Authors: Srám, R J, Samková, I, Holá, N
• Format: Journal Article
• Language: English
• Published: Czech Republic 1983
• Subjects: Adult; Ascorbic Acid - administration & dosage; Ascorbic Acid - therapeutic use; Bis(Chloromethyl) Ether - adverse effects; Chromosome Aberrations; Humans; Lymphocyte Activation; Lymphocytes - ultrastructure; Methyl Ethers - adverse effects; Mitotic Index; Occupational Diseases - chemically induced; Occupational Diseases - genetics; Occupational Diseases - prevention & control; Smoking

A possible prophylactic effect of ascorbic acid (AA) was studied in a group of 77 workers occupationally exposed to carcinogens bis(chloromethyl) ether and chloromethyl methyl ether. The effect of prophylactic treatment was assessed by cytogenetic analysis of chromosome aberrations, and by determina...