Involvement of HIV-I nucleocapsid protein in the recruitment of reverse transcriptase into nucleoprotein complexes formed in vitro

• Published in: The Journal of biological chemistry Vol. 273; no. 50; pp. 33781 - 33786
• Main Authors: Lener, D, Tanchou, V, Roques, B P, Le Grice, S F, Darlix, J L
• Format: Journal Article
• Language: English
• Published: United States 11.12.1998
• Subjects: AIDS/HIV; Amino Acid Sequence; Capsid - genetics; Capsid - metabolism; Capsid Proteins; gag Gene Products, Human Immunodeficiency Virus; Gene Products, gag - genetics; Gene Products, gag - metabolism; HIV Reverse Transcriptase - metabolism; Human immunodeficiency virus 1; Molecular Sequence Data; Mutation; Nucleoproteins - genetics; Nucleoproteins - metabolism; Protein Binding; Transcription, Genetic; Viral Proteins

Retroviral reverse transcription takes place within the virion core, where nucleocapsid (NC) protein (NCp) molecules cover the dimeric RNA genome. NCp thus has structural roles in the virion core but is also extensively involved in viral DNA synthesis and virion assembly. To further characterize the...