The effects of dual blockade of the renin-angiotensin system on urinary protein and transforming growth factor-beta excretion in 2 groups of patients with IgA and diabetic nephropathy

• Published in: Clinical nephrology Vol. 60; no. 5; p. 318
• Main Authors: Song, J H, Lee, S W, Suh, J H, Kim, E S, Hong, S B, Kim, K A, Kim, M J
• Format: Journal Article
• Language: English
• Published: Germany 01.11.2003
• Subjects: Adult; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors - pharmacology; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Benzimidazoles - pharmacology; Benzimidazoles - therapeutic use; Cross-Over Studies; Diabetic Nephropathies - drug therapy; Diabetic Nephropathies - urine; Female; Glomerulonephritis, IGA - drug therapy; Glomerulonephritis, IGA - urine; Humans; Male; Middle Aged; Prospective Studies; Proteinuria - drug therapy; Ramipril - pharmacology; Ramipril - therapeutic use; Renin-Angiotensin System - drug effects; Tetrazoles - pharmacology; Tetrazoles - therapeutic use; Transforming Growth Factor beta - urine

The therapeutic benefits of dual blockade of the renin-angiotensin system (RAS) have been inconsistent on renal function and proteinuria. To know the contribution of the heterogeneity of study subjects to such inconsistency, we evaluated the effects of dual blockade of RAS in 2 groups of selected re...