Scaffold-based [Fe]-hydrogenase model: H2 activation initiates Fe(0)-hydride extrusion and non-biomimetic hydride transfer

• Published in: Chemical science (Cambridge) Vol. 12; no. 38; pp. 12838 - 12846
• Main Authors: Kerns, Spencer A, Seo, Junhyeok, Lynch, Vincent M, Shearer, Jason, Goralski, Sean T, Sullivan, Eileen R, Rose, Michael J
• Format: Journal Article
• Language: English
• Published: Cambridge Royal Society of Chemistry 06.10.2021; The Royal Society of Chemistry
• Subjects: Anthracene; Biomimetic materials; Carbon monoxide; Carbonyls; Chemistry; Extrusion; Hydrides; Hydrogen bonds; Hydrogenase; Iron; Ligands; Methylene; NMR; Nuclear magnetic resonance; Scaffolds; Structural analysis; Substrates

We report the synthesis and reactivity of a model of [Fe]-hydrogenase derived from an anthracene-based scaffold that includes the endogenous, organometallic acyl(methylene) donor. In comparison to other non-scaffolded acyl-containing complexes, the complex described herein retains molecularly well-d...