Effect of sodium salts of 3 alpha , 12 alpha -dihydroxy-7-oxo-5 beta -cholanoic and 3,7,12-trioxo-5 beta -cholanoic acids on verapamil hydrochloride in biophysical-chemical model experiments

• Published in: Journal of the Serbian Chemical Society Vol. 76; no. 2; pp. 189 - 199
• Main Authors: Posa, M M, Guzsvany, V J, Mikov, M M, Canadi, J J
• Format: Journal Article
• Language: English
• Published: 01.01.2011
• Subjects: Chloroform; Derivatives; Esters; Hydrochlorides; Mathematical models; Membranes; Sodium salts; Steroids

It is known that certain bile acids have a promotive effect on the action of some drugs. Special attention is paid to bile acids having oxo groups instead of OH groups in the steroid skeleton of their molecule, since these derivatives have a lower hemolytic potential (membrane toxicity). This study...