Glucose metabolism in human gliomas: correspondence of in situ and in vitro metabolic rates and altered energy metabolism

• Published in: Metabolic brain disease Vol. 1; no. 4; p. 279
• Main Authors: Galarraga, J, Loreck, D J, Graham, J F, DeLaPaz, R L, Smith, B H, Hallgren, D, Cummins, C J
• Format: Journal Article
• Language: English
• Published: United States 01.12.1986
• Subjects: Adenosine Triphosphate - metabolism; Energy Metabolism; Glioma - metabolism; Glucose - metabolism; Humans; Phosphocreatine - metabolism; Pyruvates - metabolism; Pyruvic Acid; Tumor Cells, Cultured - metabolism

The rates of disappearance of glucose from the medium of 13 human glioma-derived cell lines and one cultured of normal human cortical astrocytes were determined by fluorometric techniques. High-grade glioma-derived cultures showed a range of glucose consumption between 1 and 5 nmol/min/mg protein. N...