Post-anoxic delayed encephalopathy with leukoencephalopathy and non-hemorrhagic cerebral amyloid angiopathy

A 74 year-old woman with an early-stage senile dementia developed severe hypertonia and akinetic mutism two weeks after exposure to methane. A CT scan showed a diffuse area of decreased density extending symmetrically into the white matter of both cerebral hemispheres. Neuropathology revealed a seni...

Full description

Saved in:
Bibliographic Details
Published inClinical neuropathology Vol. 5; no. 4; p. 153
Main Authors Salama, J, Gherardi, R, Amiel, H, Poirier, J, Delaporte, P, Gray, F
Format Journal Article
LanguageEnglish
Published Germany 01.07.1986
Subjects
Aged
Alzheimer Disease - complications
Alzheimer Disease - pathology
Amyloidosis - complications
Amyloidosis - pathology
Brain - pathology
Brain Diseases - complications
Brain Diseases - pathology
Cerebrovascular Disorders - complications
Cerebrovascular Disorders - pathology
Female
Humans
Hypoxia - complications
Methane - poisoning
Online AccessGet more information

Cover

More Information
Summary:A 74 year-old woman with an early-stage senile dementia developed severe hypertonia and akinetic mutism two weeks after exposure to methane. A CT scan showed a diffuse area of decreased density extending symmetrically into the white matter of both cerebral hemispheres. Neuropathology revealed a senile dementia, Alzheimer's type, with severe non-hemorrhagic cerebral amyloid angiopathy and a diffuse spotty demyelination of the cerebral hemispheres sparing the U fibers, corpus callosum and internal capsules. The close resemblance between Grinker's myelinopathy, secondary to CO exposure or to other non-CO anoxic causes, and the leukoencephalopathy associated with cerebral amyloid angiopathy is emphasized.
ISSN:0722-5091