Bioengineering liver microtissues for modeling non-alcoholic fatty liver disease

• Published in: EXCLI JOURNAL Vol. 22; pp. 367 - 391
• Main Authors: Aasadollahei, Negar, Rezaei, Niloufar, Golroo, Reihaneh, Agarwal, Tarun, Vosough, Massoud, Piryaei, Abbas
• Format: Journal Article Publication
• Language: English
• Published: Germany Leibniz Research Centre for Working Environment and Human Factors 2023
• Subjects: Review; in vitro modeling; liver microtissue; organ-on-a-chip; non-alcoholic fatty liver disease; liver organoid; bioengineering

Non-alcoholic fatty liver disease (NAFLD) has become the world's most common chronic liver disease. However, due to the lack of reliable NAFLD models, drug development studies have faced many limitations, and there is no food and drug administration-approved medicine for NAFLD treatment. A func...