Identification and Characterization of N6-Methyladenosine CircRNAs and Methyltransferases in the Lens Epithelium Cells From Age-Related Cataract

• Published in: Investigative ophthalmology & visual science Vol. 61; no. 10; p. 13
• Main Authors: Li, Pengfei, Yu, Hualin, Zhang, Guowei, Kang, Lihua, Qin, Bai, Cao, Yu, Luo, Jiawei, Chen, Xiaojuan, Wang, Ying, Qin, Miaomiao, Wu, Jian, Huang, Yemeng, Zou, Xi, Guan, Huaijin, Wang, Yong
• Format: Journal Article
• Language: English
• Published: United States The Association for Research in Vision and Ophthalmology 03.08.2020
• Subjects: Adenosine - analogs & derivatives; Adenosine - genetics; Aged; Blotting, Western; Cataract - genetics; Cataract - metabolism; Cataract - pathology; Cells, Cultured; Epithelial Cells - metabolism; Epithelial Cells - pathology; Female; Fluorescent Antibody Technique, Indirect; Gene Expression Profiling; Genome-Wide Association Study; Humans; Lens; Lens, Crystalline - metabolism; Lens, Crystalline - pathology; Male; Methyltransferases - genetics; Middle Aged; Real-Time Polymerase Chain Reaction; RNA, Circular - genetics; Sequence Analysis, RNA; Up-Regulation

To explore the involvement of N6-methyladenosine (m6A) modification in circular RNAs (circRNAs) and relevant methyltransferases in the lesion of lens epithelium cells (LECs) under the circumstances of age-related cataract (ARC). LECs were collected from normal subjects and patients with cortical typ...