Imaging Pituitary Vasopressin 1B Receptor in Humans with the PET Radiotracer 11C-TASP699

• Published in: The Journal of nuclear medicine (1978) Vol. 63; no. 4; p. 609
• Main Authors: Naganawa, Mika, Nabulsi, Nabeel B, Matuskey, David, Henry, Shannan, Ropchan, Jim, Lin, Shu-Fei, Gao, Hong, Pracitto, Richard, Labaree, David, Zhang, Ming-Rong, Suhara, Tetsuya, Nishino, Izumi, Sabia, Helene, Ozaki, Satoshi, Huang, Yiyun, Carson, Richard E
• Format: Journal Article
• Language: English
• Published: New York Society of Nuclear Medicine 01.04.2022
• Subjects: Argipressin; Argipressin receptors; Binding; Brain; Estimates; Hypothalamic-pituitary-adrenal axis; Hypothalamus; Mental disorders; Metabolites; Neuroimaging; Occupancy; Pharmacokinetics; Pituitary (posterior); Positron emission; Positron emission tomography; Radioactive tracers; Receptors; Reproducibility; Selectivity; Tomography; Vasopressin

Arginine vasopressin is a hormone that is synthesized mainly in the hypothalamus and stored in the posterior pituitary. Receptors for vasopressin are categorized into at least 3 subtypes (V1A, V1B, and V2). Among these subtypes, the V1B receptor (V1BR), highly expressed in the pituitary, is a primar...