Oncoimmunology in old age

Physiological aging processes of the immune system are associated with an increased susceptibility to infectious, autoimmune and tumor diseases. In accordance with the general demographic development the number of tumor patients in advanced age also increases. An end to this development is not yet f...

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Bibliographic Details
Published inHNO Vol. 68; no. 3; p. 177
Main Authors Wigand, M C, Jeske, S, Hahn, J, Doescher, J, Laban, S, Hoffmann, T K, Schuler, P J
Format Journal Article
LanguageGerman
Published Germany 01.03.2020
Subjects
Aged
Aging
Head and Neck Neoplasms - immunology
Head and Neck Neoplasms - therapy
Humans
Immune System - physiology
Immunologic Factors
Immunotherapy
Checkpoint inhibitors
Immunosenescence
Head and neck neoplasms
Carcinogenesis
Immunotherapy
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Summary:Physiological aging processes of the immune system are associated with an increased susceptibility to infectious, autoimmune and tumor diseases. In accordance with the general demographic development the number of tumor patients in advanced age also increases. An end to this development is not yet foreseeable. In tumor treatment, immunotherapy with checkpoint inhibitors is becoming increasingly more important; however, only a few studies on the efficacy and side-effect profiles in older patients exist so far. In this review article the changes in the immune system in old age and the influence on carcinogenesis are discussed. In addition, the current state of research on the immunotherapy of patients in advanced age who suffer from head and neck cancer is presented.
ISSN:1433-0458
DOI:10.1007/s00106-019-00758-3