Acute toxicity and antidiabetic effect of the ethyl acetate fraction of Commelina diffusa Burm.f. on the high-fat diet and streptozotocin-induced type 2 diabetic mice

• Published in: Pakistan journal of pharmaceutical sciences Vol. 37; no. 4; p. 855
• Main Authors: Nguyen, Xuan Tung, Vu, Duc Loi, Anh Nguyen, Thi Van, Thu Nguyen, Thi Minh, Le, Hong Duong
• Format: Journal Article
• Language: English
• Published: Pakistan 01.07.2024
• Subjects: Acetates - chemistry; Animals; Blood Glucose - drug effects; Blood Glucose - metabolism; Diabetes Mellitus, Experimental - drug therapy; Diabetes Mellitus, Type 2 - drug therapy; Diet, High-Fat - adverse effects; Hypoglycemic Agents - pharmacology; Liver - drug effects; Liver - pathology; Male; Mice; Pancreas - drug effects; Pancreas - pathology; Plant Extracts - pharmacology; Streptozocin; Toxicity Tests, Acute

Pharmacological studies proved that Commelina diffusa Burm.f. performs various biological activities. Nevertheless, the scientific evidence supporting the hypoglycemic activities of this medicinal plant is insufficient. Thus, this study aims to assess the acute toxicity and the antidiabetic activity...