Headache case that responded to alendronate treatment in Paget's disease

• Published in: Aǧrı Vol. 24; no. 3; pp. 135 - 138
• Main Authors: Bozkurt, Dilek, Hiz, Fazilet, Çinar, Meral, Can, Meltem
• Format: Journal Article
• Language: Turkish
• Published: Turkey 2012
• Subjects: Aged; Alendronate - administration & dosage; Bone Density Conservation Agents - administration & dosage; Diagnosis, Differential; Headache - drug therapy; Headache - etiology; Humans; Male; Osteitis Deformans - complications; Osteitis Deformans - diagnosis; Osteitis Deformans - diagnostic imaging; Radiography
• ISSN: 1300-0012
• DOI: 10.5505/agri.2012.27576

Paget's disease of the bone is a chronic, focal skeletal disease characterized by bone pain and deformity, pathological fractures and neurological symptoms such as headache, hearing loss and tinnitus, etc. The frequency of the disease increases in later ages. Viral and genetical factors play a role in the etiology. The majority of cases are asymptomatic. It is often diagnosed with an incidental finding on radiography or with an unexpected high serum alkaline phosphatase level. Bone fractures or neurological complications can negatively affect the quality of life. Early diagnosis and treatment are thus very important. Bisphosphonates are the most frequently used medication in the treatment. We present a case who sought medical help because of headache and was diagnosed as Paget's disease. Neurological complications and the diagnosis and treatment of Paget's disease are reviewed in the literature.