Mutation signatures in head and neck squamous cell carcinoma : Pathogenesis and therapeutic potential

• Published in: HNO Vol. 68; no. 12; p. 922
• Main Authors: Plath, M, Hess, J, Zaoui, K
• Format: Journal Article
• Language: German
• Published: Germany 01.12.2020
• Subjects: Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - therapy; Head and Neck Neoplasms - genetics; Head and Neck Neoplasms - therapy; Humans; Mutation - genetics; Oropharyngeal Neoplasms; Papillomavirus Infections - complications; Prognosis; Squamous Cell Carcinoma of Head and Neck - genetics; Squamous Cell Carcinoma of Head and Neck - therapy; Gene expression signatures; Mutation; Genetic variation; Whole exome sequencing; Sequence analysis

The pathogenesis of head and neck squamous cell carcinoma (HNSCC) is a complex and multistage process which results from the interaction of exogenous and endogenous cellular processes. Each of these processes leaves a characteristic pattern of mutations on the tumor genome, a so-called mutational si...