Invasive micropapillary carcinoma component is an independent prognosticator of poorer survival in Stage III colorectal cancer patients
Invasive micropapillary carcinoma (IMPC) is an aggressive variant of adenocarcinoma found in several organs. Recent studies showed that IMPC in colorectal cancer leads to poorer prognosis than conventional colorectal cancer; however, the influence of IMPC on outcomes remains unclear. The present stu...
Saved in:
Published in | Japanese journal of clinical oncology Vol. 47; no. 12; pp. 1129 - 1134 |
---|---|
Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
01.12.2017
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Invasive micropapillary carcinoma (IMPC) is an aggressive variant of adenocarcinoma found in several organs. Recent studies showed that IMPC in colorectal cancer leads to poorer prognosis than conventional colorectal cancer; however, the influence of IMPC on outcomes remains unclear. The present study aimed to identify the clinicopathological characteristics of colorectal cancers with IMPCs, and to evaluate the prognostic significance of IMPCs per se.
We retrospectively analyzed data from 837 patients with colorectal cancer who underwent surgical treatment. We compared the clinicopathological characteristics and survival outcomes of colorectal cancer patients with IMPCs to those without.
Among 837 patients, 130 (16%) had an IMPC component, including 0 (0%) of 18, 9 (4.2%) of 215, 34 (13%) of 254, 59 (24%) of 249 and 28 (27%) of 101 patients with TNM Stages 0, I, II, III and IV, respectively. The 3-year disease-free survival (DFS) rates were significantly worse for Stage III patients with IMPC than for those without (55.3% vs. 78.7% respectively, P < 0.001), but not in patients with other stages. Multivariate analyses of patients with Stage III colorectal cancer found IMPC to be associated with significantly worse DFS (P = 0.026), as were high CEA levels, tumor budding and TNM staging. IMPC was only significantly associated with tumor invasion (P = 0.045) and venous invasion (P = 0.045) in Stage III tumors.
Identifying IMPC components in Stage III colorectal cancer is crucial, as their presence is significantly associated with poorer survival. |
---|---|
AbstractList | BACKGROUNDInvasive micropapillary carcinoma (IMPC) is an aggressive variant of adenocarcinoma found in several organs. Recent studies showed that IMPC in colorectal cancer leads to poorer prognosis than conventional colorectal cancer; however, the influence of IMPC on outcomes remains unclear. The present study aimed to identify the clinicopathological characteristics of colorectal cancers with IMPCs, and to evaluate the prognostic significance of IMPCs per se. METHODSWe retrospectively analyzed data from 837 patients with colorectal cancer who underwent surgical treatment. We compared the clinicopathological characteristics and survival outcomes of colorectal cancer patients with IMPCs to those without. RESULTSAmong 837 patients, 130 (16%) had an IMPC component, including 0 (0%) of 18, 9 (4.2%) of 215, 34 (13%) of 254, 59 (24%) of 249 and 28 (27%) of 101 patients with TNM Stages 0, I, II, III and IV, respectively. The 3-year disease-free survival (DFS) rates were significantly worse for Stage III patients with IMPC than for those without (55.3% vs. 78.7% respectively, P < 0.001), but not in patients with other stages. Multivariate analyses of patients with Stage III colorectal cancer found IMPC to be associated with significantly worse DFS (P = 0.026), as were high CEA levels, tumor budding and TNM staging. IMPC was only significantly associated with tumor invasion (P = 0.045) and venous invasion (P = 0.045) in Stage III tumors. CONCLUSIONSIdentifying IMPC components in Stage III colorectal cancer is crucial, as their presence is significantly associated with poorer survival. Invasive micropapillary carcinoma (IMPC) is an aggressive variant of adenocarcinoma found in several organs. Recent studies showed that IMPC in colorectal cancer leads to poorer prognosis than conventional colorectal cancer; however, the influence of IMPC on outcomes remains unclear. The present study aimed to identify the clinicopathological characteristics of colorectal cancers with IMPCs, and to evaluate the prognostic significance of IMPCs per se. We retrospectively analyzed data from 837 patients with colorectal cancer who underwent surgical treatment. We compared the clinicopathological characteristics and survival outcomes of colorectal cancer patients with IMPCs to those without. Among 837 patients, 130 (16%) had an IMPC component, including 0 (0%) of 18, 9 (4.2%) of 215, 34 (13%) of 254, 59 (24%) of 249 and 28 (27%) of 101 patients with TNM Stages 0, I, II, III and IV, respectively. The 3-year disease-free survival (DFS) rates were significantly worse for Stage III patients with IMPC than for those without (55.3% vs. 78.7% respectively, P < 0.001), but not in patients with other stages. Multivariate analyses of patients with Stage III colorectal cancer found IMPC to be associated with significantly worse DFS (P = 0.026), as were high CEA levels, tumor budding and TNM staging. IMPC was only significantly associated with tumor invasion (P = 0.045) and venous invasion (P = 0.045) in Stage III tumors. Identifying IMPC components in Stage III colorectal cancer is crucial, as their presence is significantly associated with poorer survival. |
Author | Kohashi, Toshihiko Matsuura, Hiroo Mukaida, Hidenori Ohdan, Hideki Kitagawa, Hiroki Emi, Manabu Hirabayashi, Naoki Ohge, Hiroki Kaneko, Mayumi Yoshimitsu, Masanori Ibuki, Yuta |
Author_xml | – sequence: 1 givenname: Hiroki surname: Kitagawa fullname: Kitagawa, Hiroki organization: Department of Surgery, Hiroshima City Asa Citizens Hospital – sequence: 2 givenname: Masanori surname: Yoshimitsu fullname: Yoshimitsu, Masanori organization: Department of Surgery, Hiroshima City Asa Citizens Hospital – sequence: 3 givenname: Mayumi surname: Kaneko fullname: Kaneko, Mayumi organization: Department of Pathology, Hiroshima City Asa Citizens Hospital – sequence: 4 givenname: Yuta surname: Ibuki fullname: Ibuki, Yuta organization: Department of Surgery, Hiroshima City Asa Citizens Hospital – sequence: 5 givenname: Manabu surname: Emi fullname: Emi, Manabu organization: Department of Surgery, Hiroshima City Asa Citizens Hospital – sequence: 6 givenname: Toshihiko surname: Kohashi fullname: Kohashi, Toshihiko organization: Department of Surgery, Hiroshima City Asa Citizens Hospital – sequence: 7 givenname: Hidenori surname: Mukaida fullname: Mukaida, Hidenori organization: Department of Surgery, Hiroshima City Asa Citizens Hospital – sequence: 8 givenname: Hiroo surname: Matsuura fullname: Matsuura, Hiroo organization: Department of Pathology, Hiroshima City Asa Citizens Hospital – sequence: 9 givenname: Hiroki surname: Ohge fullname: Ohge, Hiroki organization: Department of Infectious Diseases, Hiroshima University – sequence: 10 givenname: Hideki surname: Ohdan fullname: Ohdan, Hideki organization: Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan – sequence: 11 givenname: Naoki surname: Hirabayashi fullname: Hirabayashi, Naoki organization: Department of Surgery, Hiroshima City Asa Citizens Hospital |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29036423$$D View this record in MEDLINE/PubMed |
BookMark | eNo1kDlPxDAQhS0EYg-o6JFLmrC-cpVoxRFpJQqgjhzHXrxKbGM7EfsL-NtYYmlmpHmf3sy8FTg31kgAbjC6x6imm8NB2M3n8RvT4gwsMSvyjBYEL8AqhANCKK9YeQkWpEa0YIQuwU9jZh70LOGohbeOOz0M3B-h4F5oY0cOhR1d2mIi1AFyA7XppZOppInzdm9siFrwaD20CjprvfQwTH7WMx8SDd8i30vYNE2yGpIqYpoLbkTiHI86GYUrcKH4EOT1qa_Bx9Pj-_Yl270-N9uHXeYwwzGrEVek6queUYJqKUWleNWJnuWY8VrVqKIUKUVQT0gnpOorKpBIKlIlFl1N1-Duzzdd_jXJENtRByHTz0baKbS4zglGJS1ZQm9P6NSNsm-d12NKpv0Pj_4Cz-F1Ng |
ContentType | Journal Article |
Copyright | The Author 2017. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com |
Copyright_xml | – notice: The Author 2017. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com |
DBID | CGR CUY CVF ECM EIF NPM 7X8 |
DOI | 10.1093/jjco/hyx136 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
DatabaseTitleList | MEDLINE - Academic MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1465-3621 |
EndPage | 1134 |
ExternalDocumentID | 29036423 |
Genre | Journal Article |
GroupedDBID | --- -E4 .2P .I3 .ZR 0R~ 18M 1TH 29J 2WC 4.4 482 48X 5GY 5RE 5VS 5WA 5WD 70D AABZA AACZT AAJKP AAJQQ AAMVS AAOGV AAPNW AAPQZ AAPXW AARHZ AASNB AAUQX AAVAP ABEUO ABIXL ABJNI ABKDP ABNHQ ABNKS ABPTD ABQLI ABQNK ABSAR ABWST ABXVV ABZBJ ACGFO ACGFS ACIMA ACPRK ACUFI ACUTJ ACUTO ACYHN ADBBV ADEYI ADGZP ADHKW ADHZD ADIPN ADJQC ADOCK ADQBN ADRIX ADRTK ADVEK ADYVW ADZXQ AEGPL AEGXH AEJOX AEKSI AEMDU AENEX AENZO AEPUE AETBJ AEWNT AFFZL AFIYH AFOFC AFRAH AFXAL AFXEN AGINJ AGKEF AGQXC AGSYK AGUTN AHMBA AHXPO AIAGR AIJHB AIMBJ AJEEA ALMA_UNASSIGNED_HOLDINGS ALUQC APIBT APWMN ASMCH AWCFO AXUDD BAWUL BAYMD BCRHZ BEYMZ BGYMP BHONS BTRTY BVRKM BYORX C45 CDBKE CGR CS3 CUY CVF CZ4 DAKXR DIK DILTD DU5 D~K E3Z EBS ECM EE~ EIF EJD EMOBN ENERS F5P F9B FECEO FLUFQ FOEOM FOTVD FQBLK GAUVT GJXCC GX1 H5~ HAR HW0 HZ~ IH2 IOX J21 KAQDR KBUDW KOP KQ8 KSI KSN M-Z M49 MHKGH ML0 N9A NGC NOMLY NOYVH NPM NU- NVLIB O9- OAUYM OAWHX OCZFY ODMLO OJQWA OJZSN OK1 OPAEJ OVD OWPYF P2P PAFKI PEELM PQQKQ Q1. Q5Y RD5 RHF ROX ROZ RUSNO RW1 RXO TCURE TEORI TJX TR2 W8F WOQ X7H YAYTL YKOAZ YXANX ZKX ~91 7X8 AAUAY ATGXG H13 |
ID | FETCH-LOGICAL-p141t-90af28d8d43209eec8fa8bcd4514a9f908330ff20d22bcefd83c0c4510f71cb93 |
IngestDate | Sat Aug 17 03:04:04 EDT 2024 Thu May 23 23:39:52 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 12 |
Keywords | prognostic factors invasion colorectal tumor papillary carcinoma |
Language | English |
License | The Author 2017. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-p141t-90af28d8d43209eec8fa8bcd4514a9f908330ff20d22bcefd83c0c4510f71cb93 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
PMID | 29036423 |
PQID | 1952107374 |
PQPubID | 23479 |
PageCount | 6 |
ParticipantIDs | proquest_miscellaneous_1952107374 pubmed_primary_29036423 |
PublicationCentury | 2000 |
PublicationDate | 2017-Dec-01 20171201 |
PublicationDateYYYYMMDD | 2017-12-01 |
PublicationDate_xml | – month: 12 year: 2017 text: 2017-Dec-01 day: 01 |
PublicationDecade | 2010 |
PublicationPlace | England |
PublicationPlace_xml | – name: England |
PublicationTitle | Japanese journal of clinical oncology |
PublicationTitleAlternate | Jpn J Clin Oncol |
PublicationYear | 2017 |
SSID | ssj0005847 |
Score | 2.246946 |
Snippet | Invasive micropapillary carcinoma (IMPC) is an aggressive variant of adenocarcinoma found in several organs. Recent studies showed that IMPC in colorectal... BACKGROUNDInvasive micropapillary carcinoma (IMPC) is an aggressive variant of adenocarcinoma found in several organs. Recent studies showed that IMPC in... |
SourceID | proquest pubmed |
SourceType | Aggregation Database Index Database |
StartPage | 1129 |
SubjectTerms | Adult Aged Aged, 80 and over Carcinoma, Papillary - pathology Colorectal Neoplasms - pathology Disease-Free Survival Female Humans Male Middle Aged Multivariate Analysis Neoplasm Invasiveness Neoplasm Staging Prognosis Retrospective Studies Tumor Burden |
Title | Invasive micropapillary carcinoma component is an independent prognosticator of poorer survival in Stage III colorectal cancer patients |
URI | https://www.ncbi.nlm.nih.gov/pubmed/29036423 https://search.proquest.com/docview/1952107374 |
Volume | 47 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lj9MwELbKIiEuiDfLS0biVoVNnLRJjgi2aujucmmlcopsJ2azq8ZVHgvlD_AD-MPMxE2aikVauESR3bhR5tM87JlvCHkLQYMIgjG3xrYHAYrHhMWl41ngKaiRr4LAVVjgfHo2ni68T8vRcjD41ctaqivxTv64tq7kf6QKYyBXrJL9B8l2i8IA3IN84QoShuuNZBzlV7xJP19hWt2ar7GFULFBummZ5XrFm4xxneN5f4ZkzMOs63pbNalZuUaeZgy8m9RnrQtkd65Bf1w1bBzojH5Nh1EUDZHeGtUjEoogVIqWk7Xcc3DB-GJTyz4lRVd9qXO5t4s_y2B1_q3xX6dZoS-znRIqz7H0qqxNQVHJc110szP4i0ttZjb1qhuPRG26cH-pK97fzwAbucsNSY0O9sYjC-yq01fShpazBSPrqVx0GHvm23HM5ugfpsHQZl1cSHi9yfnmu-NeQ8F99jmeLE5O4vnxcn6L3GZ-OMKI_mM02-UNgT3fFnrCkke44JFZ7u9BSuOszO-Te9sog743kHlABmn-kNw53eZRPCI_W-TQfeTQDjm0Qw7NSspz2kMO3UcO1Yoa5NAWOfBr2iCHAnLoDjnUIIe2yHlMFpPj-YeptW3JYa0dz6ms0OaKBUmQeC6zwzSVgeKBkIkHfjcPVQgOvWsrxeyEMSFTlQSutCXM2sp3pAjdJ-Qgh5d_Rmjip7jZEArBUk8livvKSUPFklHiCjEWh-RN-zVjUHl4jgXg0nUZOyH4nGCafO-QPDWfOV4bbpaYhXiwztznN3j6Bbm7A-BLclAVdfoKXMxKvG5E_hv2lIzK |
link.rule.ids | 315,786,790,27957,27958 |
linkProvider | Flying Publisher |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Invasive+micropapillary+carcinoma+component+is+an+independent+prognosticator+of+poorer+survival+in+Stage+III+colorectal+cancer+patients&rft.jtitle=Japanese+journal+of+clinical+oncology&rft.au=Kitagawa%2C+Hiroki&rft.au=Yoshimitsu%2C+Masanori&rft.au=Kaneko%2C+Mayumi&rft.au=Ibuki%2C+Yuta&rft.date=2017-12-01&rft.eissn=1465-3621&rft.volume=47&rft.issue=12&rft.spage=1129&rft.epage=1134&rft_id=info:doi/10.1093%2Fjjco%2Fhyx136&rft.externalDBID=NO_FULL_TEXT |