Long-Lived Plasma Cells Are Contained within the CD19(-)CD38(hi)CD138(+) Subset in Human Bone Marrow

• Published in: Immunity (Cambridge, Mass.) Vol. 43; no. 1; p. 132
• Main Authors: Halliley, Jessica L, Tipton, Christopher M, Liesveld, Jane, Rosenberg, Alexander F, Darce, Jaime, Gregoretti, Ivan V, Popova, Lana, Kaminiski, Denise, Fucile, Christopher F, Albizua, Igor, Kyu, Shuya, Chiang, Kuang-Yueh, Bradley, Kyle T, Burack, Richard, Slifka, Mark, Hammarlund, Erika, Wu, Hao, Zhao, Liping, Walsh, Edward E, Falsey, Ann R, Randall, Troy D, Cheung, Wan Cheung, Sanz, Iñaki, Lee, F Eun-Hyung
• Format: Journal Article
• Language: English
• Published: United States 21.07.2015
• Subjects: ADP-ribosyl Cyclase 1 - metabolism; Adult; Aged; Antibodies, Viral - blood; Antibodies, Viral - immunology; Antigens, CD19 - metabolism; Bone Marrow Cells - immunology; Humans; Immunoglobulin Heavy Chains - genetics; Immunoglobulin Heavy Chains - immunology; Measles virus - immunology; Membrane Glycoproteins - metabolism; Middle Aged; Mumps virus - immunology; Plasma Cells - immunology; RNA, Messenger - genetics; Syndecan-1 - metabolism; Young Adult; plasmablasts; vaccine; proteomics; long-lived plasma cells; next generation sequencing; antibody secreting cells; mumps infection; plasma cells; human; measles; bone marrow; heterogeneity

Antibody responses to viral infections are sustained for decades by long-lived plasma cells (LLPCs). However, LLPCs have yet to be characterized in humans. Here we used CD19, CD38, and CD138 to identify four PC subsets in human bone marrow (BM). We found that the CD19(-)CD38(hi)CD138(+) subset was m...