Vortioxetine: a new antidepressant to treat depressive episodes

• Published in: Encéphale Vol. 42; no. 1; p. 48
• Main Authors: Colle, R, Corruble, E
• Format: Journal Article
• Language: French
• Published: France 01.02.2016
• Subjects: Antidepressive Agents, Second-Generation - pharmacology; Antidepressive Agents, Second-Generation - therapeutic use; Depressive Disorder, Major - drug therapy; Depressive Disorder, Major - psychology; Humans; Piperazines - pharmacology; Piperazines - therapeutic use; Psychiatric Status Rating Scales; Recurrence; Serotonin Agents - pharmacology; Serotonin Agents - therapeutic use; Sulfides - pharmacology; Sulfides - therapeutic use; Antidepressant; Depression; Efficacy; Psychopharmacologie; Tolérance; Major depressive disorder; Épisode dépressif caractérisé; Dépression; Vortioxétine; Antidépresseur; Efficacité; Psychopharmacology; Thérapeutique; Therapeutics; Trouble dépressif caractérisé; Major depressive episode; Safety; Vortioxetine

Vortioxetine is a new antidepressant, which mechanism of action is multimodal, targeting the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT3, 5-HT7 receptors and the serotonin transporter (5-HTT). Its efficacy and safety were assessed in fourteen studies including more than 3700 patients with a major depressive episo...