ANO1 protein as a potential biomarker for esophageal cancer prognosis and precancerous lesion development prediction

• Published in: Oncotarget Vol. 7; no. 17; pp. 24374 - 24382
• Main Authors: Shang, Li, Hao, Jia-Jie, Zhao, Xue-Ke, He, Jian-Zhong, Shi, Zhi-Zhou, Liu, Hui-Juan, Wu, Li-Fei, Jiang, Yan-Yi, Shi, Feng, Yang, Hai, Zhang, Yu, Liu, Yi-Zhen, Zhang, Tong-Tong, Xu, Xin, Cai, Yan, Jia, Xue-Mei, Li, Min, Zhan, Qi-Min, Li, En-Min, Wang, Li-Dong, Wei, Wen-Qiang, Wang, Ming-Rong
• Format: Journal Article
• Language: English
• Published: United States 26.04.2016
• Subjects: Anoctamin-1 - biosynthesis; Biomarkers, Tumor - metabolism; Carcinoma, Squamous Cell - diagnosis; Carcinoma, Squamous Cell - metabolism; Disease Progression; Esophageal Neoplasms - diagnosis; Esophageal Neoplasms - metabolism; Esophagus - metabolism; Esophagus - pathology; Female; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Proteins - biosynthesis; Precancerous Conditions - diagnosis; Precancerous Conditions - metabolism; Prognosis; ANO1; esophageal squamous cell carcinoma; biomarker; prognosis; precancerous lesions

Anoctamin 1 (ANO1) has been found to be overexpressed in esophageal squamous cell carcinoma (ESCC) in our previous study. Herein we showed the clinical relevance of ANO1 alterations with ESCC and esophageal precancerous lesion progression. ANO1 was detected in 38.1% (109/286) and 25.4% (77/303) of t...