Expression of G protein-coupled receptor 19 in human lung cancer cells is triggered by entry into S-phase and supports G(2)-M cell-cycle progression

• Published in: Molecular cancer research Vol. 10; no. 10; p. 1343
• Main Authors: Kastner, Stefan, Voss, Tilman, Keuerleber, Simon, Glöckel, Christina, Freissmuth, Michael, Sommergruber, Wolfgang
• Format: Journal Article
• Language: English
• Published: United States 01.10.2012
• Subjects: Binding Sites; Carcinoma, Small Cell - genetics; Carcinoma, Small Cell - pathology; Cell Count; Cell Division - genetics; Cell Line, Tumor; Cell Proliferation; G2 Phase - genetics; G2 Phase Cell Cycle Checkpoints - genetics; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Genes, Reporter - genetics; Histones - metabolism; Humans; Luciferases - metabolism; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Phosphorylation; Promoter Regions, Genetic - genetics; Protein Binding - genetics; Receptors, G-Protein-Coupled - genetics; Receptors, G-Protein-Coupled - metabolism; Receptors, Neurotransmitter - genetics; Receptors, Neurotransmitter - metabolism; RNA Interference; RNA, Messenger - genetics; RNA, Messenger - metabolism; RNA, Small Interfering - metabolism; S Phase - genetics; Transcription Factors - metabolism

It has long been known that G protein-coupled receptors (GPCR) are subject to illegitimate expression in tumor cells. Presumably, hijacking the normal physiologic functions of GPCRs contributes to all biologic capabilities acquired during tumorigenesis. Here, we searched for GPCRs that were expresse...