Efficacy and Safety of Sphingosine 1-Phosphate Receptor Modulators for Ulcerative Colitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

• Published in: Journal of clinical gastroenterology Vol. 58; no. 8; p. 753
• Main Authors: Mahmud, Omar, Fatimi, Asad Saulat, Mahar, Muhammad Umar, Jahangir, Arshia, Kashif, Aleena, Abbas, Manzar, Waljee, Akbar K, Berinstein, Jeffrey A
• Format: Journal Article
• Language: English
• Published: United States 01.09.2024
• Subjects: Colitis, Ulcerative - drug therapy; Humans; Randomized Controlled Trials as Topic; Remission Induction; Severity of Illness Index; Sphingosine 1 Phosphate Receptor Modulators - adverse effects; Sphingosine 1 Phosphate Receptor Modulators - therapeutic use; Sphingosine-1-Phosphate Receptors; Treatment Outcome

Sphingosine 1-phosphate receptor modulators (S1PRMs) are an effective treatment for ulcerative colitis (UC). This review summarizes all available randomized trial data on the efficacy and safety of S1PRM therapy. Multiple publication databases were systematically searched for randomized control tria...