Efficacy and Safety of Sphingosine 1-Phosphate Receptor Modulators for Ulcerative Colitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Sphingosine 1-phosphate receptor modulators (S1PRMs) are an effective treatment for ulcerative colitis (UC). This review summarizes all available randomized trial data on the efficacy and safety of S1PRM therapy. Multiple publication databases were systematically searched for randomized control tria...
Saved in:
Published in | Journal of clinical gastroenterology Vol. 58; no. 8; p. 753 |
---|---|
Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.09.2024
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Abstract | Sphingosine 1-phosphate receptor modulators (S1PRMs) are an effective treatment for ulcerative colitis (UC). This review summarizes all available randomized trial data on the efficacy and safety of S1PRM therapy.
Multiple publication databases were systematically searched for randomized control trials (RCTs) of adults with moderate to severe UC treated with S1PRMs. Random effects meta-analysis was performed. The risk of bias was assessed using the Cochrane Risk-of-Bias 2 tool, and the overall quality of evidence was rated using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach.
We identified 7 RCTs (1737 patients) involving the use of S1PRMs for moderate to severe UC. During induction, S1PRM therapy was efficacious when compared with placebo for clinical remission [RR: 2.65 (95% CI: 2.00, 3.53)], clinical response [RR: 1.68 (95% CI: 1.48, 1.91)], endoscopic improvement [RR: 2.17 (95% CI: 1.76, 2.68)], endoscopic normalization [RR: 2.56 (95% CI: 1.58, 3.83)], mucosal healing [RR: 2.88 (95% CI: 1.94, 4.26)], and histologic remission [RR: 2.42 (95% CI: 1.60, 3.66)]. Similar results were seen throughout the maintenance peroid, although fewer data were available to pool; notably, both sustained [RR: 3.57 (95% CI: 1.23, 10.35)] and steroid-free [RR: 2.92 (95% CI: 1.35, 6.33)] remission were significantly increased by S1PRM. There were no significant differences in adverse events [RR: 1.02 (95% CI: 0.90, 1.15)] and infections [RR: 1.15 (95% CI: 0.82, 1.60)] between S1PRM and placebo.
Pooling of RCT data confirms that S1PRM therapy is both effective and safe for patients with moderate to severe UC. |
---|---|
AbstractList | Sphingosine 1-phosphate receptor modulators (S1PRMs) are an effective treatment for ulcerative colitis (UC). This review summarizes all available randomized trial data on the efficacy and safety of S1PRM therapy.
Multiple publication databases were systematically searched for randomized control trials (RCTs) of adults with moderate to severe UC treated with S1PRMs. Random effects meta-analysis was performed. The risk of bias was assessed using the Cochrane Risk-of-Bias 2 tool, and the overall quality of evidence was rated using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach.
We identified 7 RCTs (1737 patients) involving the use of S1PRMs for moderate to severe UC. During induction, S1PRM therapy was efficacious when compared with placebo for clinical remission [RR: 2.65 (95% CI: 2.00, 3.53)], clinical response [RR: 1.68 (95% CI: 1.48, 1.91)], endoscopic improvement [RR: 2.17 (95% CI: 1.76, 2.68)], endoscopic normalization [RR: 2.56 (95% CI: 1.58, 3.83)], mucosal healing [RR: 2.88 (95% CI: 1.94, 4.26)], and histologic remission [RR: 2.42 (95% CI: 1.60, 3.66)]. Similar results were seen throughout the maintenance peroid, although fewer data were available to pool; notably, both sustained [RR: 3.57 (95% CI: 1.23, 10.35)] and steroid-free [RR: 2.92 (95% CI: 1.35, 6.33)] remission were significantly increased by S1PRM. There were no significant differences in adverse events [RR: 1.02 (95% CI: 0.90, 1.15)] and infections [RR: 1.15 (95% CI: 0.82, 1.60)] between S1PRM and placebo.
Pooling of RCT data confirms that S1PRM therapy is both effective and safe for patients with moderate to severe UC. |
Author | Fatimi, Asad Saulat Waljee, Akbar K Jahangir, Arshia Abbas, Manzar Kashif, Aleena Mahar, Muhammad Umar Mahmud, Omar Berinstein, Jeffrey A |
Author_xml | – sequence: 1 givenname: Omar surname: Mahmud fullname: Mahmud, Omar organization: Medical College, Aga Khan University – sequence: 2 givenname: Asad Saulat surname: Fatimi fullname: Fatimi, Asad Saulat organization: Medical College, Aga Khan University – sequence: 3 givenname: Muhammad Umar surname: Mahar fullname: Mahar, Muhammad Umar organization: Medical College, Aga Khan University – sequence: 4 givenname: Arshia surname: Jahangir fullname: Jahangir, Arshia organization: Medical College, Aga Khan University – sequence: 5 givenname: Aleena surname: Kashif fullname: Kashif, Aleena organization: Medical College, Aga Khan University – sequence: 6 givenname: Manzar surname: Abbas fullname: Abbas, Manzar organization: Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan – sequence: 7 givenname: Akbar K surname: Waljee fullname: Waljee, Akbar K organization: Department of Learning Health Sciences, University of Michigan – sequence: 8 givenname: Jeffrey A surname: Berinstein fullname: Berinstein, Jeffrey A organization: Department of Internal Medicine, Division of Gastroenterology and Hepatology, Michigan Medicine, Ann Arbor, MI |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39145668$$D View this record in MEDLINE/PubMed |
BookMark | eNpNkOtKAzEQhYMo9qJvIJIX2JpLt7vxXylahRall98lm0xsZHezbNLK-jQ-qvEGzp9z5oMzB2aATmtXA0JXlIwoEdnNcjYfkX_DCMtOUJ-mXCSMcNpDA-9fCaEZ5_Qc9big43Qyyfvo484Yq6TqsKw1XksDocPO4HWzt_WL87YGTJPnvfPNXgbAK1DQBNfipdOHUkbnsYnrtlTQymCPgGeutMH6WzzF684HqCJWMXi08PbdsoQgk2kty85b_1W2itRV9h10DNehdWUZ7aa1svQX6MxEgctfHaLt_d1m9pAsnuaPs-kiaeiYhoSlaS6J0mmuIaNKCEE15YILQUQxAeCZBGEUMK3BsDxTBc0h1UVOSRGZYUN0_XO3ORQV6F3T2kq23e7vVewTs9RvnQ |
ContentType | Journal Article |
Copyright | Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved. |
Copyright_xml | – notice: Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved. |
DBID | CGR CUY CVF ECM EIF NPM |
DOI | 10.1097/MCG.0000000000002027 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1539-2031 |
ExternalDocumentID | 39145668 |
Genre | Meta-Analysis Review Systematic Review Journal Article |
GroupedDBID | --- .-D .XZ .Z2 0R~ 4Q1 4Q2 4Q3 5GY 5RE 5VS 71W 8L- AAAAV AAHPQ AAIQE AAMTA AARTV AASCR AAUEB AAWTL AAYEP ABASU ABBUW ABDIG ABJNI ABVCZ ABXVJ ABZAD ACDDN ACEWG ACGFO ACGFS ACILI ACNWC ACWDW ACWRI ACXJB ACXNZ ADGGA ADHPY AE6 AENEX AFDTB AFSOK AFUWQ AGINI AHQNM AHVBC AINUH AJIOK AJNWD AJZMW ALMA_UNASSIGNED_HOLDINGS ALMTX AMJPA AMKUR AMNEI AOHHW AWKKM BQLVK C45 CGR CS3 CUY CVF DIWNM DU5 E.X EBS ECM EEVPB EIF EX3 F2K F2L F5P FCALG FL- GNXGY GQDEL H0~ HLJTE HZ~ IKREB IN~ IPNFZ JK3 JK8 K8S KD2 KMI L-C L7B N9A NPM O9- OAG OAH ODA OJAPA OL1 OLG OLV OLW OLZ OPUJH OVD OVDNE OVOZU OWBYB OWU OWV OWW OWX OWY OWZ OXXIT P2P RIG RLZ RXW S4R S4S TAF TEORI TSPGW V2I VVN W3M WOQ WOW X3V X3W XXN XYM YFH YOC ZFV |
ID | FETCH-LOGICAL-p141t-2558a0cd58de71c9991d13939909b6ee37ae9fce2ddef287cb18e5db810b2ddf2 |
IngestDate | Sat Nov 02 12:05:52 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 8 |
Language | English |
License | Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved. |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-p141t-2558a0cd58de71c9991d13939909b6ee37ae9fce2ddef287cb18e5db810b2ddf2 |
PMID | 39145668 |
ParticipantIDs | pubmed_primary_39145668 |
PublicationCentury | 2000 |
PublicationDate | 2024-Sep-01 |
PublicationDateYYYYMMDD | 2024-09-01 |
PublicationDate_xml | – month: 09 year: 2024 text: 2024-Sep-01 day: 01 |
PublicationDecade | 2020 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | Journal of clinical gastroenterology |
PublicationTitleAlternate | J Clin Gastroenterol |
PublicationYear | 2024 |
SSID | ssj0017331 |
Score | 2.4688685 |
SecondaryResourceType | review_article |
Snippet | Sphingosine 1-phosphate receptor modulators (S1PRMs) are an effective treatment for ulcerative colitis (UC). This review summarizes all available randomized... |
SourceID | pubmed |
SourceType | Index Database |
StartPage | 753 |
SubjectTerms | Colitis, Ulcerative - drug therapy Humans Randomized Controlled Trials as Topic Remission Induction Severity of Illness Index Sphingosine 1 Phosphate Receptor Modulators - adverse effects Sphingosine 1 Phosphate Receptor Modulators - therapeutic use Sphingosine-1-Phosphate Receptors Treatment Outcome |
Title | Efficacy and Safety of Sphingosine 1-Phosphate Receptor Modulators for Ulcerative Colitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
URI | https://www.ncbi.nlm.nih.gov/pubmed/39145668 |
Volume | 58 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ba9swFBZpB6UvZfdu64Ye9ja8WYkvct9CaFcK6QZNoG9Fso6XQh2bJXnpr-lv2y_pOZIcO107tuXBGCm-SOdDOjr-9B3GPmoD_dCEeRCrOAwiBTLQSiZBlIR5LEUE4Fi-Z8nJNDq9iC96vV8d1tJqqT_nNw_uK_kfq2IZ2pV2yf6DZdc3xQI8R_viES2Mx7-y8RHpP1C-dsu_VAU4esV5TWGlihjtn0TwfVYt6hm6lOQiQo1rbEqARlm7KM8OsQyn1zl4AfCRpcMt3H7181bl2evvW1YGLFWwoWWCpVV5dUOxYkd8v8bTiW3_I77vej_mD7XAC0gX9OdGfH-sZuXKgu9bqdb84WN8l9LSD4YLRS2mVnQucWTx8WqmyhLrp51LTxVFxq9c6m6ibqtuvKMfrQldOF01Y3SGMPCThx_EY9kBq-yMyKnTIv5tpnAKxOPRV6dg6X8UCur-Hbu7Li16BplAX9OlAPpz7T397qZqi22lkpKLnFE8yX_nooyZzYbOLP3y0Ovssp3mFveWPtYFmjxle95-fOiA-Iz1YP6c7Yw9O-MFu23wyBER3OGRVwXv4JF38MgbPPIWjxzxyFs8co_HQz7kLRq5Q6N9ygYa6WEtGnmLRu7Q-JJNj48mo5PAZwAJahGJZYDrXanC3MTSQCpyWswYXLKgUx1mOgEYpAqyIoc-TtIFrv1zLSTERksRaiwr-q_Y9ryawz5pE5hEJBDrVJhIQiZByTwrkkFkMnTK9Rv22vXtZe1kXi6bXn_7aM07ttsi9IA9KbAl8B6d1KX-YO18Bxabl9M |
link.rule.ids | 780 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Efficacy+and+Safety+of+Sphingosine+1-Phosphate+Receptor+Modulators+for+Ulcerative+Colitis%3A+A+Systematic+Review+and+Meta-Analysis+of+Randomized+Controlled+Trials&rft.jtitle=Journal+of+clinical+gastroenterology&rft.au=Mahmud%2C+Omar&rft.au=Fatimi%2C+Asad+Saulat&rft.au=Mahar%2C+Muhammad+Umar&rft.au=Jahangir%2C+Arshia&rft.date=2024-09-01&rft.eissn=1539-2031&rft.volume=58&rft.issue=8&rft.spage=753&rft_id=info:doi/10.1097%2FMCG.0000000000002027&rft_id=info%3Apmid%2F39145668&rft_id=info%3Apmid%2F39145668&rft.externalDocID=39145668 |