Pulmonary tuberculosis treatment regimen recommended by the Brazilian National Ministry of Health: predictors of treatment noncompliance in the city of Porto Alegre, Brazil

• Published in: Jornal brasileiro de pneumologia Vol. 37; no. 6; pp. 776 - 782
• Main Authors: Campani, Simone Teresinha Aloise, Moreira, José da Silva, Tietbohel, Carlos Nunes
• Format: Journal Article
• Language: English; Portuguese
• Published: Brazil 01.11.2011
• Subjects: Adult; Age Factors; Alcoholism - epidemiology; Brazil - epidemiology; Epidemiologic Methods; Female; Government Agencies; HIV Infections - epidemiology; Humans; Male; National Health Programs; Patient Compliance - statistics & numerical data; Residence Characteristics - statistics & numerical data; Risk Factors; Tuberculosis, Pulmonary - drug therapy; Tuberculosis, Pulmonary - ethnology; Brazil
• ISSN: 1806-3756
• DOI: 10.1590/S1806-37132011000600011

To determine the predictors of noncompliance with the pulmonary tuberculosis treatment regimen recommended by the Brazilian National Ministry of Health, in previously treatment-naïve patients with active tuberculosis treated in the city of Porto Alegre, Brazil. This was a case-control study involving six referral primary health care clinics for tuberculosis in Porto Alegre. We reviewed the medical charts of all previously treatment-naïve patients with active pulmonary tuberculosis who were noncompliant with the treatment between 2004 and 2006. Those were paired with other patients having similar characteristics and having been cured. We conducted univariate and multivariate analyses. Of the 2,098 patients included, 218 (10.4%) became noncompliant with the treatment. In the multivariate analysis, the factors most strongly associated with treatment noncompliance were being an alcoholic (with or without concomitant use of illicit drugs), being HIV-infected, not residing with family members, and having a low level of education. In the univariate analysis, treatment noncompliance was also significantly associated with being younger and with being non-White. Gender was not significantly associated with treatment noncompliance; nor was the occurrence of adverse effects of the drugs included in the regimen. In the population studied, being an alcoholic, being HIV-infected, and not residing with family members were the major predictors of noncompliance with treatment for pulmonary tuberculosis among previously treatment-naïve patients.