White matter correlates of apathy in HIV-positive subjects: a diffusion tensor imaging study

• Published in: The journal of neuropsychiatry and clinical neurosciences Vol. 22; no. 3; p. 313
• Main Authors: Hoare, Jacqueline, Fouche, Jean-Paul, Spottiswoode, Bruce, Joska, John A, Schoeman, Renata, Stein, Dan J, Carey, Paul D
• Format: Journal Article
• Language: English
• Published: United States 01.07.2010
• Subjects: Adolescent; Adult; Analysis of Variance; Brain Mapping; Corpus Callosum - physiopathology; Diffusion Tensor Imaging; Female; Gyrus Cinguli - physiopathology; HIV Seropositivity - physiopathology; HIV Seropositivity - psychology; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Mood Disorders - physiopathology; Mood Disorders - psychology; Nerve Fibers, Myelinated; Psychiatric Status Rating Scales; Regression Analysis

Apathy is commonly reported by patients infected with HIV. No previous work has assessed the relationship between white matter and apathy in HIV. The authors aimed to determine whether apathy in HIV reflects a direct effect of the virus on subcortical brain regions or a secondary neuropsychiatric sy...