The role of GABA(A) receptors in the acute and chronic effects of ethanol: a decade of progress

• Published in: Psychopharmacology (Berlin, Germany) Vol. 205; no. 4; p. 529
• Main Authors: Kumar, Sandeep, Porcu, Patrizia, Werner, David F, Matthews, Douglas B, Diaz-Granados, Jaime L, Helfand, Rebecca S, Morrow, A Leslie
• Format: Journal Article
• Language: English
• Published: Germany 01.09.2009
• Subjects: Adolescent; Adolescent Behavior - drug effects; Animals; Behavior, Animal - drug effects; Brain - drug effects; Brain - metabolism; Drug Tolerance - physiology; Ethanol - administration & dosage; Ethanol - pharmacology; gamma-Aminobutyric Acid - metabolism; Humans; Mice; Models, Biological; Neural Inhibition - drug effects; Neurons - drug effects; Neurons - metabolism; Receptors, GABA-A - drug effects; Receptors, GABA-A - genetics; Receptors, GABA-A - metabolism; Signal Transduction - drug effects; Synaptic Transmission - drug effects

The past decade has brought many advances in our understanding of GABA(A) receptor-mediated ethanol action in the central nervous system. We now know that specific GABA(A) receptor subtypes are sensitive to ethanol at doses attained during social drinking while other subtypes respond to ethanol at d...