Retroelement demethylation associated with abnormal placentation in Mus musculus x Mus caroli hybrids

• Published in: Biology of reproduction Vol. 86; no. 3; p. 88
• Main Authors: Brown, Judith D, Piccuillo, Vanessa, O'Neill, Rachel J
• Format: Journal Article
• Language: English
• Published: United States 01.03.2012
• Subjects: Animals; Chimera - genetics; DNA Methylation - genetics; DNA Methylation - physiology; Female; Genomic Instability - genetics; Hybridization, Genetic - genetics; Karyotype; Mice - genetics; Mice, Inbred Strains - genetics; Models, Animal; Placentation - genetics; Placentation - physiology; Pregnancy; Retroelements - genetics; Retroelements - physiology

The proper functioning of the placenta requires specific patterns of methylation and the appropriate regulation of retroelements, some of which have been co-opted by the genome for placental-specific gene expression. Our inquiry was initiated to determine the causes of the placental defects observed...