Dexamethasone stimulates store-operated calcium entry and protein degradation in cultured L6 myotubes through a phospholipase A(2)-dependent mechanism

• Published in: American Journal of Physiology: Cell Physiology Vol. 298; no. 5; pp. C1127 - C1139
• Main Authors: Itagaki, Kiyoshi, Menconi, Michael, Antoniu, Bozena, Zhang, Qin, Gonnella, Patricia, Soybel, David, Hauser, Carl, Hasselgren, Per-Olof
• Format: Journal Article
• Language: English
• Published: United States 01.05.2010
• Subjects: Animals; Calcium Signaling - physiology; Dexamethasone - pharmacology; Gene Expression Regulation; Gene Silencing; Muscle Fibers, Skeletal - drug effects; Muscle Fibers, Skeletal - metabolism; Phospholipases A2 - metabolism; Rats; Receptors, Glucocorticoid - metabolism; RNA Interference; RNA, Messenger - genetics; RNA, Messenger - metabolism; RNA, Small Interfering; Tissue Culture Techniques

Muscle wasting in various catabolic conditions is at least in part regulated by glucocorticoids. Increased calcium levels have been reported in atrophying muscle. Mechanisms regulating calcium homeostasis in muscle wasting, in particular the role of glucocorticoids, are poorly understood. Here we te...