Active and passive transport of drugs in the human placenta

• Published in: Ginekologia polska Vol. 80; no. 10; p. 772
• Main Authors: Włoch, Stanisław, Pałasz, Artur, Kamiński, Marcin
• Format: Journal Article
• Language: English
• Published: Poland 01.10.2009
• Subjects: ATP Binding Cassette Transporter, Sub-Family B - metabolism; ATP-Binding Cassette Transporters - metabolism; Biological Transport; Cytochrome P-450 Enzyme System - metabolism; Drug-Related Side Effects and Adverse Reactions - metabolism; Female; Humans; Maternal-Fetal Exchange - drug effects; Maternal-Fetal Exchange - physiology; Microvilli - metabolism; Pharmaceutical Preparations - metabolism; Placenta - drug effects; Placenta - metabolism; Pregnancy; Xenobiotics - pharmacokinetics

The human placenta, characterized by the processes of passive transport and facilitated diffusion, contains numerous active transport proteins, usually located in the microvilli of the syncytiotrophoblast or in the endothelium of the capillaries of the villi. These proteins use either the energy fro...