Ocular safety of INS365 ophthalmic solution: a P2Y(2) agonist in healthy subjects

• Published in: Journal of ocular pharmacology and therapeutics Vol. 17; no. 2; p. 173
• Main Authors: Mundasad, M V, Novack, G D, Allgood, V E, Evans, R M, Gorden, J C, Yerxa, B R
• Format: Journal Article
• Language: English
• Published: United States 01.04.2001
• Subjects: Administration, Topical; Adult; Cohort Studies; Double-Blind Method; Dry Eye Syndromes - drug therapy; Female; Humans; Lacrimal Apparatus - drug effects; Lacrimal Apparatus - secretion; Male; Middle Aged; Mucins - metabolism; Ophthalmic Solutions - administration & dosage; Ophthalmic Solutions - adverse effects; Ophthalmic Solutions - pharmacology; Polyphosphates; Purinergic P2 Receptor Agonists; Receptors, Purinergic P2 - metabolism; Safety; Tears - secretion; Uracil Nucleotides

The purpose of this study was to evaluate the ocular safety and tolerability of the P2Y(2) receptor agonist, INS365, when applied as eye drops in normal human subjects. This study was a double-masked, placebo-controlled, randomized, within subject paired-comparison, dose-escalation study in five coh...