Rolipram, a phosphodiesterase type IV inhibitor, exacerbates periventricular white matter lesions in rat pups

• Published in: Pediatric research Vol. 64; no. 3; pp. 234 - 239
• Main Authors: Chang, Ying-Chao, Huang, Chao-Ching, Hung, Pi-Lien, Huang, Hsiu-Mei
• Format: Journal Article
• Language: English
• Published: United States 01.09.2008
• Subjects: Animals; Animals, Newborn; Astrocytes - drug effects; Astrocytes - metabolism; Astrocytes - pathology; Brain - pathology; Cell Proliferation - drug effects; Cerebral Ventricles; Cyclic AMP Response Element-Binding Protein - metabolism; Disease Models, Animal; Dose-Response Relationship, Drug; Hypoxia-Ischemia, Brain - metabolism; Hypoxia-Ischemia, Brain - pathology; Male; Oligodendroglia - drug effects; Oligodendroglia - metabolism; Oligodendroglia - pathology; Phosphodiesterase 4 Inhibitors; Rats; Rats, Sprague-Dawley; Rolipram - pharmacology; Signal Transduction - drug effects; Signal Transduction - physiology

Periventricular white matter injury is the leading cause of cerebral palsy in premature infants for which no effective treatments are available. Our previous studies have demonstrated that pharmacological activation of the cAMP response element-binding protein (CREB) signaling pathway, before hypoxi...