The risk of obesity and the Trp64Arg polymorphism of the beta(3)-adrenergic receptor: effect modification by age

• Published in: Annals of nutrition and metabolism Vol. 46; no. 3-4; pp. 152 - 158
• Main Authors: Corbalán, M S, Marti, A, Forga, L, Martínez-Gonzalez, M A, Martínez, J A
• Format: Journal Article
• Language: English
• Published: Switzerland 2002
• Subjects: Adult; Age Factors; Arginine - genetics; Case-Control Studies; Electrophoresis, Gel, Two-Dimensional; Female; Humans; Male; Middle Aged; Obesity - genetics; Odds Ratio; Polymorphism, Genetic - genetics; Receptors, Adrenergic, beta-3 - genetics; Risk; Spain; Tryptophan - genetics; Spain
• ISSN: 0250-6807
• DOI: 10.1159/000063084

To examine the association between the risk of obesity and the Trp64Arg polymorphism of the beta(3)-adrenergic receptor gene. A case-control study was conducted. The case series encompassed 159 subjects with a body mass index >30 kg/m(2) (obesity) and no other major diseases except for type 2 diabetes, and the controls were 154 healthy subjects with a body mass index <25 kg/m(2). 313 Spanish subjects between 20 and 60 years of age were screened for the Trp64Arg mutation. The prevalence of the Trp64Arg mutation was similar among cases (19.5%) and control subjects (16.2%). The association between the risk of obesity and the Trp64Arg mutation was estimated using multivariate logistic regression. A higher odds ratio of 3.84 (95% CI 1.33-11.12) for the mutation was found among younger individuals (20-35 years), while no increased risk was apparent among older participants (35-60 years). Moreover, when the model was adjusted for gender, age, and leisure-time physical activity, the product-term for interaction (effect modification) between age and the presence of the Trp64Arg mutation was statistically significant (likelihood ratio test p = 0.035). Individuals aged 20-35 years who are Trp64Arg carriers had a substantially higher risk of developing obesity, independent of their sex or leisure-time physical activity.