A current problem in atherothrombotic diseases--aspirin resistance: definition, mechanisms, determination with laboratory tests and clinical implications
Aspirin (acetylsalicylic acid) is a powerful antiplatelet agent used in prevention of atherothrombotic vascular events. However, antiplatelet effect of aspirin is not uniform and some patients could not benefit from aspirin. These patients are clinically called as aspirin resistant or aspirin non-re...
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Published in | Anadolu kardiyoloji dergisi : AKD Vol. 7 Suppl 2; p. 20 |
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Main Authors | , , |
Format | Journal Article |
Language | Turkish |
Published |
Turkey
01.12.2007
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Abstract | Aspirin (acetylsalicylic acid) is a powerful antiplatelet agent used in prevention of atherothrombotic vascular events. However, antiplatelet effect of aspirin is not uniform and some patients could not benefit from aspirin. These patients are clinically called as aspirin resistant or aspirin non-responders. Aspirin resistance could be determined by: bleeding time, optical aggregometry, PFA-100 (Platelet Function Analyzer), Ultegra-RPFA (Rapid Platelet Function Assay), activated aggregation time, whole blood aggregometry, platelet aggregate ratio, flow cytometry, measurements of platelet surface proteins and blood or urine thromboxane B2 levels. Mechanisms of aspirin resistance have not been elucidated yet. There is evidence that aspirin resistance increases clinical cardiovascular events. Adequate additional therapies may reduce atherothrombotic risks and major cardiovascular events rate in aspirin resistant subjects. However, we need further studies to decrease major cardiovascular events risk in aspirin resistant subjects and to optimize antiplatelet therapy. |
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AbstractList | Aspirin (acetylsalicylic acid) is a powerful antiplatelet agent used in prevention of atherothrombotic vascular events. However, antiplatelet effect of aspirin is not uniform and some patients could not benefit from aspirin. These patients are clinically called as aspirin resistant or aspirin non-responders. Aspirin resistance could be determined by: bleeding time, optical aggregometry, PFA-100 (Platelet Function Analyzer), Ultegra-RPFA (Rapid Platelet Function Assay), activated aggregation time, whole blood aggregometry, platelet aggregate ratio, flow cytometry, measurements of platelet surface proteins and blood or urine thromboxane B2 levels. Mechanisms of aspirin resistance have not been elucidated yet. There is evidence that aspirin resistance increases clinical cardiovascular events. Adequate additional therapies may reduce atherothrombotic risks and major cardiovascular events rate in aspirin resistant subjects. However, we need further studies to decrease major cardiovascular events risk in aspirin resistant subjects and to optimize antiplatelet therapy. |
Author | Oflaz, Hüseyin Nişanci, Yilmaz Pamukçu, Burak |
Author_xml | – sequence: 1 givenname: Burak surname: Pamukçu fullname: Pamukçu, Burak email: burakpamukcu@ttnet.net.tr organization: Istanbul Universitesi, Istanbul Tip Fakültesi, Kardiyoloji Anabilim Dali, Istanbul, Türkiye. burakpamukcu@ttnet.net.tr – sequence: 2 givenname: Hüseyin surname: Oflaz fullname: Oflaz, Hüseyin – sequence: 3 givenname: Yilmaz surname: Nişanci fullname: Nişanci, Yilmaz |
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DocumentTitleAlternate | Aterotrombotik hastaliklarda güncel bir sorun--aspirin direnci: tanimi, oluşum mekanizmalari, laboratuvar yöntemleri ile belirlenmesi ve klinik sonuçlari |
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Snippet | Aspirin (acetylsalicylic acid) is a powerful antiplatelet agent used in prevention of atherothrombotic vascular events. However, antiplatelet effect of aspirin... |
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SubjectTerms | Aspirin - administration & dosage Aspirin - adverse effects Blood Platelets - drug effects Coronary Thrombosis - prevention & control Drug Resistance Humans Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - adverse effects Platelet Function Tests |
Title | A current problem in atherothrombotic diseases--aspirin resistance: definition, mechanisms, determination with laboratory tests and clinical implications |
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