Treatment of acneiform rash by epidermal growth factor inhibitors with oral tetracyclines

• Published in: Actas dermo-sifiliográficas Vol. 97; no. 8; p. 503
• Main Authors: Fernández-Guarino, Montse, Pérez García, Bibiana, Aldanondo Fernández de la Mora, Isabel, García-Millán, Cristina, Garrido López, Pilar, Jaén Olasolo, Pedro
• Format: Journal Article
• Language: Spanish
• Published: Spain 01.10.2006
• Subjects: Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents - administration & dosage; Antineoplastic Agents - adverse effects; Doxycycline - administration & dosage; Drug Eruptions - drug therapy; Drug Eruptions - etiology; Erlotinib Hydrochloride; Female; Follow-Up Studies; Humans; Male; Middle Aged; Protein Kinase Inhibitors - adverse effects; Quinazolines - adverse effects; Receptor, Epidermal Growth Factor - antagonists & inhibitors; Time Factors; Treatment Outcome

Epidermal growth factor inhibitors (EGFR) are new antineoplastic agents that are increasingly being developed. They are basically used as second line treatment in advanced stage tumors. Appearance of a facial acneiform rash in patients treated with these drugs is common and characteristic. The liter...