TNF-alpha dependent production of inducible nitric oxide is involved in PGE(1) protection against acute liver injury

• Published in: Gut Vol. 47; no. 4; p. 553
• Main Authors: Muntané, J, Rodríguez, F J, Segado, O, Quintero, A, Lozano, J M, Siendones, E, Pedraza, C A, Delgado, M, O'Valle, F, García, R, Montero, J L, De La Mata, M, Miño, G
• Format: Journal Article
• Language: English
• Published: England 01.10.2000
• Subjects: Alanine Transaminase - blood; Alprostadil - metabolism; Animals; Antibodies - immunology; Galactosamine; Liver Failure, Acute - chemically induced; Liver Failure, Acute - metabolism; Male; Nitric Oxide - metabolism; Nitric Oxide Synthase - antagonists & inhibitors; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha - immunology; Tumor Necrosis Factor-alpha - physiology

Tumour necrosis factor alpha (TNF-alpha) and nitric oxide modulate damage in several experimental models of liver injury. We have previously shown that protection against D-galactosamine (D-GalN) induced liver injury by prostaglandin E(1) (PGE(1)) was accompanied by an increase in TNF-alpha and nitr...