Alternative RNA splicing generates diversity of neuropeptide expression in the brain of the snail Lymnaea: in situ analysis of mutually exclusive transcripts of the FMRFamide gene

• Published in: The European journal of neuroscience Vol. 7; no. 1; p. 65
• Main Authors: Santama, N, Benjamin, P R, Burke, J F
• Format: Journal Article
• Language: English
• Published: France 01.01.1995
• Subjects: Amino Acid Sequence; Animals; Axons - ultrastructure; Base Sequence; Brain - physiology; DNA, Complementary; Gene Expression; Immunohistochemistry; In Situ Hybridization; Lymnaea; Molecular Sequence Data; Neuropeptides - genetics; Oligonucleotides; RNA Splicing - genetics; RNA Splicing - physiology; RNA, Messenger; Sequence Analysis, DNA

In the CNS of the snail Lymnaea stagnalis, Phe-Met-Arg-Phe-amide (FMRFamide)-like and additional novel neuropeptides are encoded by a common, multi-exon gene. This complex locus, comprising at least five exons, is subject to post-transcriptional regulation at the level of alternative RNA splicing. O...