Verapamil competitively inhibits alpha 1-adrenergic and muscarinic but not beta-adrenergic receptors in rat myocardium

• Published in: Journal of cardiovascular pharmacology Vol. 4; no. 3; p. 515
• Main Authors: Karliner, J S, Motulsky, H J, Dunlap, J, Brown, J H, Insel, P A
• Format: Journal Article
• Language: English
• Published: United States 01.05.1982
• Subjects: Adrenergic alpha-Antagonists; Animals; Binding, Competitive - drug effects; Dihydroalprenolol - metabolism; Gallopamil - pharmacology; Heart - drug effects; In Vitro Techniques; Male; Parasympatholytics; Prazosin - metabolism; Quinuclidinyl Benzilate - metabolism; Rats; Rats, Inbred Strains; Receptors, Adrenergic - drug effects; Receptors, Adrenergic, beta - drug effects; Verapamil - pharmacology

Recent studies indicate that antagonism of calcium channels may not be the only mechanism whereby drugs such as verapamil alter myocardial function. We have examined the effect of verapamil on the binding of [3H]prazosin (alpha 1-adrenergic), [3H]quinuclidinyl benzilate (QNB, muscarinic) and [3H]dih...