The platelet reactivity of the alpha 2(I)-chain of type I collagen: platelet aggregation induced by polymers of the molecule [alpha 2(I)]3

• Published in: Thrombosis research Vol. 39; no. 4; pp. 523 - 531
• Main Authors: Fitzsimmons, C M, Barnes, M J
• Format: Journal Article
• Language: English
• Published: United States 15.08.1985
• Subjects: Animals; Cattle; Collagen; Humans; Macromolecular Substances; Platelet Aggregation; Protein Conformation; Structure-Activity Relationship; Temperature

Polymers of the collagenous species alpha 2(I) trimer, a molecule of which contains three alpha 2(I) chains derived from type I collagen, have been shown to induce the aggregation of platelets when tested at a temperature low enough to avoid loss of the tertiary structure of the molecule. Under thes...