Effects of low‐dose aspirin on gastric erosions, cyclooxygenase expression and mucosal prostaglandin‐E2 do not depend on Helicobacter pylori infection

• Published in: Alimentary pharmacology & therapeutics Vol. 23; no. 8; pp. 1225 - 1233
• Main Authors: VENERITO, M., TREIBER, G., WEX, T., KUESTER, D., ROESSNER, A., DI MARIO, F., MALFERTHEINER, P.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 15.04.2006; Blackwell
• Subjects: Adult; Anti-Bacterial Agents - therapeutic use; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; Anti-Inflammatory Agents, Non-Steroidal - adverse effects; Aspirin - administration & dosage; Aspirin - adverse effects; Biological and medical sciences; Case-Control Studies; Cyclooxygenase 1 - analysis; Cyclooxygenase 1 - metabolism; Cyclooxygenase 2 - analysis; Cyclooxygenase 2 - metabolism; Digestive system; Dinoprostone - analysis; Dinoprostone - metabolism; Drug Administration Schedule; Enzyme-Linked Immunosorbent Assay; Female; Gastric Mucosa - drug effects; Gastric Mucosa - metabolism; Gastric Mucosa - pathology; Gastroenterology. Liver. Pancreas. Abdomen; Helicobacter Infections - drug therapy; Helicobacter Infections - metabolism; Helicobacter Infections - pathology; Helicobacter pylori; Humans; Immunohistochemistry - methods; Male; Medical sciences; Pharmacology. Drug treatments; Prostaglandin-Endoperoxide Synthases - analysis; Prostaglandin-Endoperoxide Synthases - metabolism; Reverse Transcriptase Polymerase Chain Reaction; Statistics, Nonparametric; Stomach; Prostaglandin-endoperoxide synthase; Spirillales; Digestive system; Enzyme; Arachidonic acid derivatives; Low dose; Mucosa; Enzyme inhibitor; Spirillaceae; Prostaglandin E2; Acetylsalicylic acid; Antiplatelet agent; Infection; Non steroidal antiinflammatory agent; Analgesic; Helicobacter pylori; Eicosanoid; Antipyretic; Bacteriosis; Bacteria; Oxidoreductases; Salicylates; Erosion

Summary Background  The mechanisms by which Helicobacter pylori and low‐dose aspirin induce gastric damage are not completely elucidated. Aim  To evaluate the effects of low‐dose aspirin on gastric damage, mucosal prostaglandin‐E2 levels and cyclooxygenase‐enzyme expression in relation to the H. pyl...