Coexistence of D3R typical and atypical signaling in striatonigral neurons during dopaminergic denervation. Correlation with D3nf expression changes

• Published in: Synapse (New York, N.Y.) Vol. 74; no. 8
• Main Authors: Campos Campos, Baruc, Ávalos‐Fuentes, Arturo, Piña Leyva, Celia, Sánchez‐Zavaleta, Rodolfo, Loya‐López, Santiago, Rangel‐Barajas, Claudia, Leyva‐Gómez, Gerardo, Cortés, Hernán, Erlij, David, Florán, Benjamín
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 01.08.2020
• Subjects: Agonists; Alternative splicing; Basal ganglia; Coexistence; Cyclic AMP; D3 receptors; D3nf; Denervation; Dopamine D1 receptors; Dopamine D3 receptors; GABA release; Isoforms; mRNA; Neostriatum; Neurons; Parkinson's disease; striatonigral projections; striatum; substantia nigra reticulata; Turning behavior; γ-Aminobutyric acid

Dopamine D3R are widely expressed in basal ganglia where interact with D1R. D3R potentiate cAMP accumulation and GABA release stimulated by D1R in striatonigral neurons through “atypical” signaling. During dopaminergic denervation, D3R signaling changes to a “typical” in which antagonizes the effect...