Subcellular localization of PDE4D and HCN1 in rhesus macaque entorhinal cortex layer II: Signature of vulnerability in Alzheimer’s disease

• Published in: Alzheimer's & dementia Vol. 17; pp. e054671 - n/a
• Main Authors: Datta, Dibyadeep, Mentone, SueAnn, Morozov, Yury, van Dyck, Christopher H, Arnsten, Amy F. T.
• Format: Journal Article
• Language: English
• Published: United States 01.12.2021
• ISSN: 1552-5260; 1552-5279
• DOI: 10.1002/alz.054671

Background Tau pathology emerges in a distinct spatial and temporal pattern in Alzheimer’s Disease (AD). Anatomical studies in AD subjects and rhesus macaques show earliest signs of tau pathology in the stellate cell islands in entorhinal cortex (ERC) layer II. However, the molecular mechanisms that...