Potassium-induced potentiation of subtetanic force in rat skeletal muscles: influences of β2-activation, lactic acid, and temperature

• Published in: American Journal of Physiology: Cell Physiology Vol. 321; no. 5; pp. C884 - C896
• Main Authors: Olesen, Jonas H, Herskind, Jon, Pedersen, Katja K, Overgaard, Kristian
• Format: Journal Article
• Language: English
• Published: Bethesda American Physiological Society 01.11.2021
• Subjects: Acids; Adrenergic receptors; Anthracene; Carboxylic acids; Chloride conductance; Contractility; Electrical stimuli; Isometric; Lactic acid; Muscle contraction; Potassium; Salbutamol; Skeletal muscle

Moderate elevations of extracellular K+ concentration ([K+]o) occur during exercise and have been shown to potentiate force during contractions elicited with subtetanic frequencies. Here, we investigated whether lactic acid (reduced chloride conductance), β2-adrenoceptor activation, and increased te...