肝硬化患者血清CA125水平与肝损害程度相关性的Meta分析

目的探讨肝硬化患者血清CA125与肝功能损害程度的关系。方法检索万方科技期刊全文数据库、中国学术期刊 (CNKI) 全文数据库、中国生物医学文献数据库 (CBM) 、维普 (VIP) 中文科技期刊全文数据库于2008年1月-2018年10月发表的有关CA125与肝硬化患者肝损害程度相关性的中文文献,每篇文献均需设立肝硬化组及正常对照组。采用观察性流行病学研究报告规范 (STROBE) 为参考标准来评价入选文献质量。合并各文献肝硬化组和健康对照组、肝硬化组各Child-Pugh分级组CA125均数及标准差。采用Meta-Analyst软件计算文献中各组CA125标准化均值差 (SMD) 进行Me...

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Published inLinchuang gandanbing zazhi Vol. 35; no. 4; pp. 796 - 800
Main Authors 邵翠萍, 徐有青
Format Journal Article
LanguageChinese
Published Changchun Journal of Clinical Hepatology 01.04.2019
首都医科大学附属北京天坛医院消化内科,北京,100070
Subjects
Liver cirrhosis
Meta-analysis
CA-125抗原
Child-Pugh分级
Meta分析
肝硬化
Online AccessGet full text
ISSN1001-5256
2097-3497
DOI10.3969/j.issn.1001-5256.2019.04.018

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Abstract 目的探讨肝硬化患者血清CA125与肝功能损害程度的关系。方法检索万方科技期刊全文数据库、中国学术期刊 (CNKI) 全文数据库、中国生物医学文献数据库 (CBM) 、维普 (VIP) 中文科技期刊全文数据库于2008年1月-2018年10月发表的有关CA125与肝硬化患者肝损害程度相关性的中文文献,每篇文献均需设立肝硬化组及正常对照组。采用观察性流行病学研究报告规范 (STROBE) 为参考标准来评价入选文献质量。合并各文献肝硬化组和健康对照组、肝硬化组各Child-Pugh分级组CA125均数及标准差。采用Meta-Analyst软件计算文献中各组CA125标准化均值差 (SMD) 进行Meta分析,对纳入的各研究进行异质性分析,如果各研究间存在显著异质性,则采用随机效应模型进行分析;如果各研究间异质性不显著,则采用固定效应模型进行分析。计量资料多组间比较采用单因素方差分析。结果共有15篇文献纳入研究。Meta分析结果显示,肝硬化组CA125水平显著高于健康对照组[ (181. 18±110. 76) U/ml vs (15. 10±7. 15) U/ml],差异有统计学意义 (SMD=2. 28,95%可...
AbstractList R575.2; 目的 探讨肝硬化患者血清CA125与肝功能损害程度的关系.方法 检索万方科技期刊全文数据库、中国学术期刊(CNKI)全文数据库、中国生物医学文献数据库(CBM)、维普(VIP)中文科技期刊全文数据库于2008年1月-2018年10月发表的有关CA125与肝硬化患者肝损害程度相关性的中文文献,每篇文献均需设立肝硬化组及正常对照组.采用观察性流行病学研究报告规范(STROBE)为参考标准来评价入选文献质量.合并各文献肝硬化组和健康对照组、肝硬化组各Child-Pugh分级组CA125均数及标准差.采用Meta-Analyst软件计算文献中各组CA125标准化均值差(SMD)进行Meta分析,对纳入的各研究进行异质性分析,如果各研究间存在显著异质性,则采用随机效应模型进行分析;如果各研究间异质性不显著,则采用固定效应模型进行分析.计量资料多组间比较采用单因素方差分析.结果 共有15篇文献纳入研究.Meta分析结果显示,肝硬化组CA125水平显著高于健康对照组[(181.18±110.76)U/ml vs(15.10±7.15)U/ml],差异有统计学意义(SMD=2.28,95％可信区间:1.81～2.76,P<0.001).随着肝功能Child-Pugh分级升高,CA125水平也显著升高,差异具有统计学意义(F=15.704,P<0.001).结论 肝硬化患者血清CA125水平与肝损害程度有相关性,对于评估肝硬化患者肝损害程度、判断预后具有一定的指导意义.
目的探讨肝硬化患者血清CA125与肝功能损害程度的关系。方法检索万方科技期刊全文数据库、中国学术期刊 (CNKI) 全文数据库、中国生物医学文献数据库 (CBM) 、维普 (VIP) 中文科技期刊全文数据库于2008年1月-2018年10月发表的有关CA125与肝硬化患者肝损害程度相关性的中文文献,每篇文献均需设立肝硬化组及正常对照组。采用观察性流行病学研究报告规范 (STROBE) 为参考标准来评价入选文献质量。合并各文献肝硬化组和健康对照组、肝硬化组各Child-Pugh分级组CA125均数及标准差。采用Meta-Analyst软件计算文献中各组CA125标准化均值差 (SMD) 进行Meta分析,对纳入的各研究进行异质性分析,如果各研究间存在显著异质性,则采用随机效应模型进行分析;如果各研究间异质性不显著,则采用固定效应模型进行分析。计量资料多组间比较采用单因素方差分析。结果共有15篇文献纳入研究。Meta分析结果显示,肝硬化组CA125水平显著高于健康对照组[ (181. 18±110. 76) U/ml vs (15. 10±7. 15) U/ml],差异有统计学意义 (SMD=2. 28,95%可...
Author 邵翠萍
徐有青
AuthorAffiliation 首都医科大学附属北京天坛医院消化内科,北京,100070
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Child-Pugh分级
Meta分析
肝硬化
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PublicationTitle_FL Journal of Clinical Hepatology
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首都医科大学附属北京天坛医院消化内科,北京,100070
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Snippet 目的探讨肝硬化患者血清CA125与肝功能损害程度的关系。方法检索万方科技期刊全文数据库、中国学术期刊 (CNKI) 全文数据库、中国生物医学文献数据库 (CBM) 、维普 (VIP)...
R575.2; 目的 探讨肝硬化患者血清CA125与肝功能损害程度的关系.方法...
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SubjectTerms Liver cirrhosis
Meta-analysis
Title 肝硬化患者血清CA125水平与肝损害程度相关性的Meta分析
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