血清肝纤维化指标对肝纤维化的诊断价值
目的探讨血清肝纤维化指标Ⅲ型前胶原蛋白 (PCⅢ) 、Ⅳ型胶原蛋白 (C-Ⅳ) 、透明质酸 (HA) 、层粘连蛋白 (LN) ,即肝纤维化四项对肝纤维化诊断的价值。方法回顾性分析2018年4月-2019年4月西南医科大学附属医院收治的155例肝硬化、42例肝硬化合并原发性肝癌 (PHC) 、150例慢性肝炎和73例健康体检者的临床资料。对所有研究对象均测定血清肝纤维化四项指标,比较各组间血清学指标的差异,并绘制受试者工作特征曲线 (ROC曲线) 比较肝纤维化四项的诊断效能。符合正态分布的计量资料2组间比较采用t检验,不符合正态分布的计量资料多组间比较采用Kruskal-Wallis H秩和检验...
Saved in:
| Published in | Linchuang gandanbing zazhi Vol. 35; no. 11; pp. 2466 - 2471 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | Chinese |
| Published |
Changchun
Journal of Clinical Hepatology
01.11.2019
西南医科大学临床医学院,四川泸州,646000%西南医科大学附属医院消化内科,四川泸州,646000 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1001-5256 2097-3497 |
| DOI | 10.3969/j.issn.1001-5256.2019.11.016 |
Cover
| Abstract | 目的探讨血清肝纤维化指标Ⅲ型前胶原蛋白 (PCⅢ) 、Ⅳ型胶原蛋白 (C-Ⅳ) 、透明质酸 (HA) 、层粘连蛋白 (LN) ,即肝纤维化四项对肝纤维化诊断的价值。方法回顾性分析2018年4月-2019年4月西南医科大学附属医院收治的155例肝硬化、42例肝硬化合并原发性肝癌 (PHC) 、150例慢性肝炎和73例健康体检者的临床资料。对所有研究对象均测定血清肝纤维化四项指标,比较各组间血清学指标的差异,并绘制受试者工作特征曲线 (ROC曲线) 比较肝纤维化四项的诊断效能。符合正态分布的计量资料2组间比较采用t检验,不符合正态分布的计量资料多组间比较采用Kruskal-Wallis H秩和检验,2组间进一步比较采用Wilcoxon秩和检验。计数资料组间比较采用χ2检验。结果肝硬化患者、肝硬化合并PHC患者血清肝纤维化四项指标的水平及阳性检出率均高于慢性肝炎患者和健康体检者 (P值均<0. 05) ,但肝硬化患者与肝硬化合并PHC患者PCⅢ、C-Ⅳ和HA水平及阳性检出率比较,差异均无统计学意义 (P值均> 0. 05) 。虽然肝硬化合并PHC患者的LN水平高于肝硬化患者 (P <0... |
|---|---|
| AbstractList | R575.2; 目的 探讨血清肝纤维化指标Ⅲ型前胶原蛋白(PCⅢ)、Ⅳ型胶原蛋白(C-Ⅳ)、透明质酸(HA)、层粘连蛋白(LN),即肝纤维化四项对肝纤维化诊断的价值.方法 回顾性分析2018年4月-2019年4月西南医科大学附属医院收治的155例肝硬化、42例肝硬化合并原发性肝癌(PHC)、150例慢性肝炎和73例健康体检者的临床资料.对所有研究对象均测定血清肝纤维化四项指标,比较各组间血清学指标的差异,并绘制受试者工作特征曲线(ROC曲线)比较肝纤维化四项的诊断效能.符合正态分布的计量资料2组间比较采用t检验,不符合正态分布的计量资料多组间比较采用Kruskal-Wallis H秩和检验,2组间进一步比较采用Wilc-oxon秩和检验.计数资料组间比较采用χ2检验.结果 肝硬化患者、肝硬化合并PHC患者血清肝纤维化四项指标的水平及阳性检出率均高于慢性肝炎患者和健康体检者(P值均<0.05),但肝硬化患者与肝硬化合并PHC患者PCⅢ、C-Ⅳ和HA水平及阳性检出率比较,差异均无统计学意义(P值均>0.05).虽然肝硬化合并PHC患者的LN水平高于肝硬化患者(P<0.05),但两者阳性检出率差异无统计学意义(P>0.05).酒精性肝硬化患者PCⅢ、C-Ⅳ水平明显高于病毒性肝炎肝硬化、病毒性合并酒精性肝硬化及自身免疫性肝硬化患者(P值均<0.05),自身免疫性肝硬化、酒精性肝硬化、病毒性合并酒精性肝硬化患者的HA水平均高于病毒性肝炎肝硬化患者(P值均<0.05),病毒性肝炎肝硬化、病毒性合并酒精性肝硬化、酒精性肝硬化LN水平均高于自身免疫性肝硬化患者(P值均<0.05).不同病因慢性肝炎患者肝纤维化四项指标水平及阳性检出率均低于肝硬化组(P值均<0.05),其中病毒性肝炎(重度)患者四项指标阳性检出率均高于其余各组患者(P值均<0.05).PCⅢ、C-Ⅳ、HA、LN单独及四项指标联合检测诊断肝硬化的ROC曲线下面积分别为0.836、0.832、0.895、0.808、0.901.HA的ROC曲线下面积大于PCⅢ、C-Ⅳ、LN(P值均<0.05),但HA与四项指标联合检测的ROC曲线下面积比较差异无统计学意义(P>0.05).结论 HA对肝纤维化具有较高的诊断效能. 目的探讨血清肝纤维化指标Ⅲ型前胶原蛋白 (PCⅢ) 、Ⅳ型胶原蛋白 (C-Ⅳ) 、透明质酸 (HA) 、层粘连蛋白 (LN) ,即肝纤维化四项对肝纤维化诊断的价值。方法回顾性分析2018年4月-2019年4月西南医科大学附属医院收治的155例肝硬化、42例肝硬化合并原发性肝癌 (PHC) 、150例慢性肝炎和73例健康体检者的临床资料。对所有研究对象均测定血清肝纤维化四项指标,比较各组间血清学指标的差异,并绘制受试者工作特征曲线 (ROC曲线) 比较肝纤维化四项的诊断效能。符合正态分布的计量资料2组间比较采用t检验,不符合正态分布的计量资料多组间比较采用Kruskal-Wallis H秩和检验,2组间进一步比较采用Wilcoxon秩和检验。计数资料组间比较采用χ2检验。结果肝硬化患者、肝硬化合并PHC患者血清肝纤维化四项指标的水平及阳性检出率均高于慢性肝炎患者和健康体检者 (P值均<0. 05) ,但肝硬化患者与肝硬化合并PHC患者PCⅢ、C-Ⅳ和HA水平及阳性检出率比较,差异均无统计学意义 (P值均> 0. 05) 。虽然肝硬化合并PHC患者的LN水平高于肝硬化患者 (P <0... |
| Author | 张宇 唐世孝 |
| AuthorAffiliation | 西南医科大学临床医学院,四川泸州,646000%西南医科大学附属医院消化内科,四川泸州,646000 |
| AuthorAffiliation_xml | – name: 西南医科大学临床医学院,四川泸州,646000%西南医科大学附属医院消化内科,四川泸州,646000 |
| Author_FL | TANG Shixiao ZHANG Yu |
| Author_FL_xml | – sequence: 1 fullname: ZHANG Yu – sequence: 2 fullname: TANG Shixiao |
| Author_xml | – sequence: 1 fullname: 张宇 – sequence: 2 fullname: 唐世孝 |
| BookMark | eNpNz09LAkEYBvAhDNrMT1GHLru978zs7MwxpH8gdKmzzLgzosiuuUngSaIQwrOHICjoGl6C_tjHydWPkWFUpxcefjwP7zopJGliCdlCCJgSaqcZNLIsCRAA_ZCGIqCAKkAMAMUK8SioyGdcRQXi_Zo1UsqyhoEQmVA8FB4R84d-_no9v7ybvT_OJs_T4SgfDvL7wXT89j-c3V7Nxzf56Olz8jLtf2yQVadbmS393CI53d87KR_6leODo_JuxW8jQ-mjFNpEEQ2tU0yDBG7AAefMWUCnQxkrbWqOmpjHTkiFTFoZWUslGMsZZ0Wyvey90InTSb3aTLudZLFYbdXqsen1vp9GBJQLurmk7U561rXZ-Z9llANVlFHJvgAY2W1M |
| ClassificationCodes | R575.2 |
| ContentType | Journal Article |
| Copyright | 2019. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| Copyright_xml | – notice: 2019. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| DBID | 3V. 7X7 7XB 88E 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH K9. M0S M1P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI 2B. 4A8 92I 93N PSX TCJ |
| DOI | 10.3969/j.issn.1001-5256.2019.11.016 |
| DatabaseName | ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central ProQuest One ProQuest Central ProQuest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) ProQuest Health & Medical Collection Medical Database ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition Wanfang Data Journals - Hong Kong WANFANG Data Centre Wanfang Data Journals 万方数据期刊 - 香港版 China Online Journals (COJ) China Online Journals (COJ) |
| DatabaseTitle | Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Health & Medical Research Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) |
| DatabaseTitleList | Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| DocumentTitle_FL | Value of serum liver fibrosis markers in the diagnosis of liver fibrosis |
| EISSN | 2097-3497 |
| EndPage | 2471 |
| ExternalDocumentID | lcgdbzz201911018 |
| GrantInformation_xml | – fundername: 四川省泸州市人民政府—四川医科大学科技战略合作项目(2015LZCYD-S01(9/15)) |
| GroupedDBID | -05 3V. 5XA 5XF 7X7 7XB 88E 8FI 8FJ 8FK 92F 92I ABDBF ABJNI ABUWG ACGFS ACUHS AFKRA ALMA_UNASSIGNED_HOLDINGS AZQEC BENPR CCEZO CCPQU CIEJG CW9 DWQXO EAD EAP EOJEC ESX FYUFA K9. M1P OBODZ OK1 PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI RNS TCJ TGQ U1G U5O 2B. 4A8 93N IPNFZ PSX RIG |
| ID | FETCH-LOGICAL-p1318-186ab7725ef93a0804b0f0443fe01fa58d9abcf2bd4df689138e87ee280be4343 |
| IEDL.DBID | 7X7 |
| ISSN | 1001-5256 |
| IngestDate | Thu May 29 04:06:09 EDT 2025 Sat Aug 23 13:32:00 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 11 |
| Keywords | 诊断 肝硬化 对比研究 |
| Language | Chinese |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-p1318-186ab7725ef93a0804b0f0443fe01fa58d9abcf2bd4df689138e87ee280be4343 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 |
| OpenAccessLink | https://www.proquest.com/docview/3240292328?pq-origsite=%requestingapplication% |
| PQID | 3240292328 |
| PQPubID | 7350069 |
| PageCount | 6 |
| ParticipantIDs | wanfang_journals_lcgdbzz201911018 proquest_journals_3240292328 |
| PublicationCentury | 2000 |
| PublicationDate | 2019-11-01 |
| PublicationDateYYYYMMDD | 2019-11-01 |
| PublicationDate_xml | – month: 11 year: 2019 text: 2019-11-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Changchun |
| PublicationPlace_xml | – name: Changchun |
| PublicationTitle | Linchuang gandanbing zazhi |
| PublicationTitle_FL | Journal of Clinical Hepatology |
| PublicationYear | 2019 |
| Publisher | Journal of Clinical Hepatology 西南医科大学临床医学院,四川泸州,646000%西南医科大学附属医院消化内科,四川泸州,646000 |
| Publisher_xml | – name: Journal of Clinical Hepatology – name: 西南医科大学临床医学院,四川泸州,646000%西南医科大学附属医院消化内科,四川泸州,646000 |
| SSID | ssib051369456 ssib061082477 ssj0041983 ssib001103858 ssib053243598 ssib002264326 ssib038074677 |
| Score | 2.1758277 |
| Snippet | 目的探讨血清肝纤维化指标Ⅲ型前胶原蛋白 (PCⅢ) 、Ⅳ型胶原蛋白 (C-Ⅳ) 、透明质酸 (HA) 、层粘连蛋白 (LN) ,即肝纤维化四项对肝纤维化诊断的价值。方法回顾性分析2018年4月-2019年4月西南医科大学附属医院收治的155例肝硬化、42例肝硬化合并原发性肝癌 (PHC)... R575.2; 目的 探讨血清肝纤维化指标Ⅲ型前胶原蛋白(PCⅢ)、Ⅳ型胶原蛋白(C-Ⅳ)、透明质酸(HA)、层粘连蛋白(LN),即肝纤维化四项对肝纤维化诊断的价值.方法... |
| SourceID | wanfang proquest |
| SourceType | Aggregation Database |
| StartPage | 2466 |
| SubjectTerms | Hepatitis Liver cirrhosis |
| Title | 血清肝纤维化指标对肝纤维化的诊断价值 |
| URI | https://www.proquest.com/docview/3240292328 https://d.wanfangdata.com.cn/periodical/lcgdbzz201911018 |
| Volume | 35 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3LSwJBGB8qSbpET3qKgddVd52d3T1FliKBEpHgTWacGSNCLYvAU0QRhGcPQVDQNbwEPf-cfPwZfbOuqZdOy-wMu8x8j_nN4_t9CIWYBaiDgn1zi1oaFrBgpaAWAOQs8I1COoSrQOF0hqSyeDdn5rwNt6p3rbLvE11HzcsFtUceUcRxBqARw96snGgqa5Q6XfVSaIwjn0tdBvps5QbTqa5HR7haVNDoEFxRXOt4iM7N1GPEwQNuGRP-qQju-mVAGrbhxm32PD2GBXvvAj_00ATs4EchtQp2iBM5cm04_FelLpE5YcUXqpMRMDt5QUuSlopDs1pyBk17cDS41dOfWTRWO5xD_rR34D6PSPfpsv1-07166Hw-d75eW_VGu37bfrxtNT-GX3bur7vNu3bj5efrrXX5vYCyycTBdkrzUi1oFR2sWtNtQhkAbROkE6OAIjGLyijGMQnSk9S0uUNZQRqMYy6JOtq0hW0JYdhRJlRw6iKaKJVLYgkFCw60xpgJCciSccYsgQW0lDqnhFr2Mlrr9z7v2Us1P5DuMtrwRmRQe1woclarqSHUFcPYyv-fWEVTqmkvYnANTZydnot1gA5nLODqRwD5tuI78SQ844nM3v4vkRrLjg |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwY2BQSTIHtjoSgfk7xTzRXNckFdhhTQQmC2BDzhxYNqamWZqlgDYK-_qZeYSaeEWYRjAxrIPthQEtq4SVieCCOiU_GTRGrg86OM4I2BoxsrAvKNQF3RoFml2FXaEBSRbeqZXlwC5bsa2nCzB-VY2M3FxDnD10obcK6BYYAhOwrqGFWWISsE1pCnSIcSKwwWSSZJBmYGJinAZ0aFqiqUWKZWJScppRUopJSpoZaBbPItXCPDXVyMIgKRW0DxNoLjMDqwloRysLA6uTq19AEKIBYmiAcjoMaJsqUgMJdLq7CdIBcqaGxmaWJojTbEyBvgQdqQfjA9s2FkbgnaKQusXE0NICsmUAGKamwNYKB4MKqN9taWapnwUuNfTgUqBla5Z6oBNKDc1Qms_s5Yl5aYl56Uj1qJsgAz-0AazgCEmxQgxMVRnCDBy-0Cl-EQazFwsbnu1ofdE09_muJc93b3naM-1ZT_uzBe1P1-9EFnw-q-XF-q5n09Y-2b39acMeUYZQmkSDGANLXn5eqgSDQrIlULWJSVJqGrAtm5SSlGSeapIKVJlmmJJolmhuIckgA_N9PDSHFscj0pMkgyI0RBCyOcnpKUlVVaAgNASdaSaF3wh5Bk6PEF-feB9PP29pBi6QNsh-RRkGlpKi0lRZYMOlJEkOmloUGBJonUABu9oGpA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E8%A1%80%E6%B8%85%E8%82%9D%E7%BA%A4%E7%BB%B4%E5%8C%96%E6%8C%87%E6%A0%87%E5%AF%B9%E8%82%9D%E7%BA%A4%E7%BB%B4%E5%8C%96%E7%9A%84%E8%AF%8A%E6%96%AD%E4%BB%B7%E5%80%BC&rft.jtitle=Linchuang+gandanbing+zazhi&rft.au=%E5%BC%A0%E5%AE%87&rft.au=%E5%94%90%E4%B8%96%E5%AD%9D&rft.date=2019-11-01&rft.pub=Journal+of+Clinical+Hepatology&rft.issn=1001-5256&rft.eissn=2097-3497&rft.volume=35&rft.issue=11&rft.spage=2466&rft_id=info:doi/10.3969%2Fj.issn.1001-5256.2019.11.016 |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Flcgdbzz%2Flcgdbzz.jpg |