肠道菌群在慢加急性肝衰竭中的变化特征及致病机制
慢加急性肝衰竭起病迅速而病死率高，预后差，且缺乏特异性药物治疗及手段。近年来，越来越多的证据表明肠道微生物群对维持人体微环境稳态的作用至关重要。利用宏基因组学全面测试肠道菌群特征可证明肠道菌群与慢性肝脏疾病发生发展方面存在交互关联。在慢加急性肝衰竭发病机制研究中，发现肠道微生物群在其致病过程中扮演重要角色。基于此，本文总结了慢加急性肝衰竭发生发展过程中肠道菌群的变化特征及其参与致病的机制途径，以期从肠道菌群调控新视角为慢加急性肝衰竭的临床治疗提供新靶点。...
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| Published in | Linchuang gandanbing zazhi Vol. 39; no. 8; pp. 1992 - 1998 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
Changchun
Journal of Clinical Hepatology
01.08.2023
广西中医药大学研究生学院,南宁530222%广西中医药大学第一附属医院科研部,南宁530023%广西中医药大学第一附属医院肝病一区,南宁530023 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1001-5256 2097-3497 |
| DOI | 10.3969/j.issn.1001-5256.2023.08.034 |
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| Abstract | 慢加急性肝衰竭起病迅速而病死率高，预后差，且缺乏特异性药物治疗及手段。近年来，越来越多的证据表明肠道微生物群对维持人体微环境稳态的作用至关重要。利用宏基因组学全面测试肠道菌群特征可证明肠道菌群与慢性肝脏疾病发生发展方面存在交互关联。在慢加急性肝衰竭发病机制研究中，发现肠道微生物群在其致病过程中扮演重要角色。基于此，本文总结了慢加急性肝衰竭发生发展过程中肠道菌群的变化特征及其参与致病的机制途径，以期从肠道菌群调控新视角为慢加急性肝衰竭的临床治疗提供新靶点。 |
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| AbstractList | 慢加急性肝衰竭起病迅速而病死率高，预后差，且缺乏特异性药物治疗及手段。近年来，越来越多的证据表明肠道微生物群对维持人体微环境稳态的作用至关重要。利用宏基因组学全面测试肠道菌群特征可证明肠道菌群与慢性肝脏疾病发生发展方面存在交互关联。在慢加急性肝衰竭发病机制研究中，发现肠道微生物群在其致病过程中扮演重要角色。基于此，本文总结了慢加急性肝衰竭发生发展过程中肠道菌群的变化特征及其参与致病的机制途径，以期从肠道菌群调控新视角为慢加急性肝衰竭的临床治疗提供新靶点。 慢加急性肝衰竭起病迅速而病死率高,预后差,且缺乏特异性药物治疗及手段.近年来,越来越多的证据表明肠道微生物群对维持人体微环境稳态的作用至关重要.利用宏基因组学全面测试肠道菌群特征可证明肠道菌群与慢性肝脏疾病发生发展方面存在交互关联.在慢加急性肝衰竭发病机制研究中,发现肠道微生物群在其致病过程中扮演重要角色.基于此,本文总结了慢加急性肝衰竭发生发展过程中肠道菌群的变化特征及其参与致病的机制途径,以期从肠道菌群调控新视角为慢加急性肝衰竭的临床治疗提供新靶点. |
| Author | 林华明 王明刚 严惠萍 王秀峰 陈桂容 |
| AuthorAffiliation | 广西中医药大学研究生学院,南宁530222%广西中医药大学第一附属医院科研部,南宁530023%广西中医药大学第一附属医院肝病一区,南宁530023 |
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| Author_FL | WANG Minggang WANG Xiufeng CHEN Guirong LIN Huaming YAN Huiping |
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| Keywords | Acute-On-Chronic Liver Failure 慢加急性肝功能衰竭 Bacterial Translocation 细菌移位 胃肠道微生物组 Gastrointestinal Microbiome |
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| Title | 肠道菌群在慢加急性肝衰竭中的变化特征及致病机制 |
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