NLRP3炎症小体在自身免疫性肝炎中的作用机制
自身免疫性肝炎 (AIH) 是由自身免疫系统攻击肝细胞所致的慢性肝炎，目前关于AIH的发病机制尚不十分明确。炎症小体是先天免疫的重要组成部分，参与多种病理生理学过程。研究表明核苷酸结合寡聚化结构域样受体蛋白3 (NLRP3) 炎性小体相关的炎性反应在AIH的发病机制中起重要作用，其主要介导促炎因子的释放和细胞焦亡，进而参与AIH的病理生理过程。因此，可以通过抑制NLRP3炎性小体的激活来延缓AIH发生发展，从而为AIH的防治提供新思路。...
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| Published in | Linchuang gandanbing zazhi Vol. 40; no. 10; pp. 2092 - 2097 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
Changchun
Journal of Clinical Hepatology
01.10.2024
甘肃中医药大学第一临床医学院,兰州 730000 宁夏医科大学总医院消化内科,银川 750001%中国人民解放军联勤保障部队第九四〇医院消化内科,兰州 730050 中国人民解放军联勤保障部队第九四〇医院消化内科,兰州 730050%中国人民解放军联勤保障部队第九四〇医院消化内科,兰州 730050 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1001-5256 2097-3497 |
| DOI | 10.12449/JCH241027 |
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| Abstract | 自身免疫性肝炎 (AIH) 是由自身免疫系统攻击肝细胞所致的慢性肝炎，目前关于AIH的发病机制尚不十分明确。炎症小体是先天免疫的重要组成部分，参与多种病理生理学过程。研究表明核苷酸结合寡聚化结构域样受体蛋白3 (NLRP3) 炎性小体相关的炎性反应在AIH的发病机制中起重要作用，其主要介导促炎因子的释放和细胞焦亡，进而参与AIH的病理生理过程。因此，可以通过抑制NLRP3炎性小体的激活来延缓AIH发生发展，从而为AIH的防治提供新思路。 |
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| AbstractList | 自身免疫性肝炎 (AIH) 是由自身免疫系统攻击肝细胞所致的慢性肝炎，目前关于AIH的发病机制尚不十分明确。炎症小体是先天免疫的重要组成部分，参与多种病理生理学过程。研究表明核苷酸结合寡聚化结构域样受体蛋白3 (NLRP3) 炎性小体相关的炎性反应在AIH的发病机制中起重要作用，其主要介导促炎因子的释放和细胞焦亡，进而参与AIH的病理生理过程。因此，可以通过抑制NLRP3炎性小体的激活来延缓AIH发生发展，从而为AIH的防治提供新思路。 自身免疫性肝炎(AIH)是由自身免疫系统攻击肝细胞所致的慢性肝炎,目前关于AIH的发病机制尚不十分明确.炎症小体是先天免疫的重要组成部分,参与多种病理生理学过程.研究表明核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)炎性小体相关的炎性反应在AIH的发病机制中起重要作用,其主要介导促炎因子的释放和细胞焦亡,进而参与AIH的病理生理过程.因此,可以通过抑制NLRP3炎性小体的激活来延缓AIH发生发展,从而为AIH的防治提供新思路. |
| Abstract_FL | Autoimmune hepatitis(AIH)is chronic hepatitis caused by the attack of live cells by the immune system,and at present,the pathogenesis of AIH remains unclear.Inflammasomes are important components of innate immunity and are involved in a variety of pathophysiological processes.Studies have shown that inflammatory response associated with nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)plays an important role in the pathogenesis of AIH,which mainly mediates the release of proinflammatory factors and pyroptosis,thereby participating in the pathophysiological process of AIH.Therefore,the development and progression of AIH can be delayed by inhibiting the activation of NLRP3 inflammasomes,which provides new ideas for the prevention and treatment of AIH. |
| Author | 李斌 邢国静 卢利霞 罗龙龙 于晓辉 张久聪 王丽菲 |
| AuthorAffiliation | 甘肃中医药大学第一临床医学院,兰州 730000;中国人民解放军联勤保障部队第九四〇医院消化内科,兰州 730050%中国人民解放军联勤保障部队第九四〇医院消化内科,兰州 730050;宁夏医科大学总医院消化内科,银川 750001%中国人民解放军联勤保障部队第九四〇医院消化内科,兰州 730050 |
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| Author_FL | LI Bin ZHANG Jiucong LUO Longlong WANG Lifei LU Lixia XING Guojing YU Xiaohui |
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| Keywords | NLR家族,热蛋白结构域包含蛋白3 NLR Family,Pyrin Domain-Containing 3 Protein 治疗学 Hepatitis,Autoimmune Therapeutics 肝炎,自身免疫性 |
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| Snippet | 自身免疫性肝炎 (AIH) 是由自身免疫系统攻击肝细胞所致的慢性肝炎，目前关于AIH的发病机制尚不十分明确。炎症小体是先天免疫的重要组成部分，参与多种病理生理学过程。研究表明核苷酸结合寡聚化结构域样受体蛋白3 (NLRP3)... ... |
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| Title | NLRP3炎症小体在自身免疫性肝炎中的作用机制 |
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