Computational exploration of molecular receptive fields in the olfactory bulb reveals a glomerulus-centric chemical map

• Published in: bioRxiv
• Main Authors: Soelter, Jan, Schumacher, Jan, Spors, Hartwig, Schmuker, Michael
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 04.09.2019
• Subjects: Aroma compounds; Artificial intelligence; Computer applications; Embedding; Learning algorithms; Machine learning; Olfaction; Olfactory bulb; Olfactory glomeruli; Smell; Statistical analysis; Structure-activity relationships

Progress in olfactory research is currently hampered by incomplete knowledge about chemical receptive ranges of primary receptors. Moreover, the chemical logic underlying the arrangement of computational units in the olfactory bulb has still not been resolved. We undertook a large-scale approach at...