Rgs12 enhances osteoclastogenesis by suppressing Nrf2 activity and promoting the formation of reactive oxygen species

• Published in: bioRxiv
• Main Authors: Hui Ng, Andrew Ying, Li, Ziqing, Jones, Megan M, Tu, Chengjian, Oursler, Merry Jo, Qu, Jun, Yang, Shuying
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 14.11.2018
• Subjects: Antioxidants; Bone loss; Bone mass; Clonal deletion; Gene deletion; Gene regulation; Osteoclastogenesis; Oxidative stress; Phosphorylation; Proteasome 26S; Proteomics; Reactive oxygen species; Redox properties; TRANCE protein; Transcription

The Regulator of G-protein Signaling 12 (Rgs12) is important for osteoclast (OC) differentiation, and its deletion in vivo protected mice against pathological bone loss. To characterize its mechanism in osteoclastogenesis, we selectively deleted Rgs12 in OC precursors using the LysM-Cre transgenic l...