Design of protein homocystamides with enhanced tumor uptake properties for (19)F magnetic resonance imaging

• Published in: Bioorganic & medicinal chemistry Vol. 23; no. 21; p. 6943
• Main Authors: Chubarov, Alexey S, Zakharova, Olga D, Koval, Olga A, Romaschenko, Alexander V, Akulov, Andrey E, Zavjalov, Evgenii L, Razumov, Ivan A, Koptyug, Igor V, Knorre, Dmitry G, Godovikova, Tatyana S
• Format: Journal Article
• Language: English
• Published: England 01.11.2015
• Subjects: Animals; Brain - metabolism; Cell Line, Tumor; Cell Survival - drug effects; Contrast Media - chemistry; Contrast Media - metabolism; Contrast Media - toxicity; Drug Design; Female; Fluorine-19 Magnetic Resonance Imaging; Free Radicals - metabolism; Homocysteine - analogs & derivatives; Homocysteine - chemistry; Homocysteine - metabolism; Humans; Mice; Mice, SCID; Microscopy, Fluorescence; Neoplasms - diagnosis; Neoplasms - diagnostic imaging; Radiography; Serum Albumin - chemistry; Serum Albumin - metabolism; Transplantation, Heterologous; Human serum albumin; Perfluorotoluene; Protein aggregation; Thiyl radical; N-homocysteinylation; Dual-labeled albumin-based molecular probe; Homocysteine thiolactone; Fluorine magnetic resonance imaging; Fluorinated homocysteine thiolactone; Glioma model

Straightforward and reliable tools for in vivo imaging of tumors can benefit the studies of cancer development, as well as contribute to successful diagnosis and treatment of cancer. (19)F NMR offers an exceptional quantitative way of in vivo imaging of the infused agents because of the lack of (19)...