Biomarkers in acute kidney injury: Evidence or paradigm?
Acute kidney injury in the critically ill represents an independent risk factor of morbidity and mortality in the short and long terms, with significant economic impacts in terms of public health costs. Currently its diagnosis is still based on the presence of oliguria and/or a gradual increase in s...
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Published in | Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia Vol. 36; no. 4; p. 339 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Spain
01.07.2016
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Abstract | Acute kidney injury in the critically ill represents an independent risk factor of morbidity and mortality in the short and long terms, with significant economic impacts in terms of public health costs. Currently its diagnosis is still based on the presence of oliguria and/or a gradual increase in serum creatinine, which make the diagnosis a delayed event and to detriment of the so-called 'therapeutic window'. The appearance of new biomarkers of acute kidney injury could potentially improve this situation, contributing to the detection of 'subclinical acute kidney injury', which could allow the precocious employment of multiple treatment strategies in order to preserve kidney function. However these new biomarkers display sensitive features that may threaten their full capacity of action, which focus specifically on their additional contribution in the early approach of the situation, given the lack of specific validated treatments for acute kidney injury. This review aims to analyze the strengths and weaknesses of these new tools in the early management of acute kidney injury. |
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AbstractList | Acute kidney injury in the critically ill represents an independent risk factor of morbidity and mortality in the short and long terms, with significant economic impacts in terms of public health costs. Currently its diagnosis is still based on the presence of oliguria and/or a gradual increase in serum creatinine, which make the diagnosis a delayed event and to detriment of the so-called 'therapeutic window'. The appearance of new biomarkers of acute kidney injury could potentially improve this situation, contributing to the detection of 'subclinical acute kidney injury', which could allow the precocious employment of multiple treatment strategies in order to preserve kidney function. However these new biomarkers display sensitive features that may threaten their full capacity of action, which focus specifically on their additional contribution in the early approach of the situation, given the lack of specific validated treatments for acute kidney injury. This review aims to analyze the strengths and weaknesses of these new tools in the early management of acute kidney injury. |
Author | Canzonieri, Romina Trimarchi, Hernán Lombi, Fernando Muryan, Alexis |
Author_xml | – sequence: 1 givenname: Fernando surname: Lombi fullname: Lombi, Fernando email: fernandolombi@gmail.com organization: Servicio de Nefrología, Hospital Británico de Buenos Aires, Buenos Aires, Argentina. Electronic address: fernandolombi@gmail.com – sequence: 2 givenname: Alexis surname: Muryan fullname: Muryan, Alexis organization: Laboratorio Central, Hospital Británico de Buenos Aires, Buenos Aires, Argentina – sequence: 3 givenname: Romina surname: Canzonieri fullname: Canzonieri, Romina organization: Laboratorio Central, Hospital Británico de Buenos Aires, Buenos Aires, Argentina – sequence: 4 givenname: Hernán surname: Trimarchi fullname: Trimarchi, Hernán organization: Servicio de Nefrología, Hospital Británico de Buenos Aires, Buenos Aires, Argentina |
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Copyright | Copyright © 2016 Sociedad Española de Nefrología. Published by Elsevier España, S.L.U. All rights reserved. |
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Keywords | Biomarkers Biomarcadores Lesión renal aguda Acute kidney injury |
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SubjectTerms | Acute Kidney Injury - blood Acute Kidney Injury - diagnosis Acute Kidney Injury - therapy Acute Kidney Injury - urine Biomarkers - blood Biomarkers - urine Blood Chemical Analysis - instrumentation Cell Cycle Checkpoints Clinical Trials as Topic Critical Illness Cystatin C - blood Early Diagnosis Evidence-Based Medicine Hepatitis A Virus Cellular Receptor 1 - blood Humans Interleukin-18 - blood Interleukin-18 - urine Lipocalin-2 - blood Multicenter Studies as Topic Neoplasm Proteins - urine Oliguria - etiology Renal Replacement Therapy |
Title | Biomarkers in acute kidney injury: Evidence or paradigm? |
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