Research progress on mechanism of myokines regulating bone tissue cells

• Published in: Zhongguo xiu fu chong jian wai ke za zhi Vol. 35; no. 7; pp. 923 - 929
• Main Authors: Peng, Hongcheng, Hua, Zhen, Yang, Huilin, Wang, Jianwei
• Format: Journal Article
• Language: Chinese
• Published: China 15.07.2021
• Subjects: Bone and Bones; Cytokines; Muscle, Skeletal; Osteoblasts; Osteoclasts; bone tissue cells; myokines; osteoporosis; Skeletal muscle; fracture
• ISSN: 1002-1892
• DOI: 10.7507/1002-1892.202012062

To review the effects and mechanisms of various myokines secreted by skeletal muscle on various bone tissue cells. Literature related to myokines and their regulation of bone tissue cells was reviewed and analyzed comprehensively in recent years. Bone and skeletal muscle are important members of the motor system, and they are closely related in anatomy, genetics, and physiopathology. In recent years, it has been found that skeletal muscle can secrete a variety of myokines to regulate bone marrow mesenchymal stem cells, osteoblasts, osteoclasts, and bone cells; these factors mutual crosstalk between myoskeletal unit, contact each other and influence each other, forming a complex myoskeletal micro-environment, and to some extent, it has a positive impact on bone repair and reconstruction. Myokines are potential targets for the dynamic balance of bone tissue cells. In-depth study of its mechanism is helpful to the prevention and treatment of myoskeletal diseases.