Clinical and physiological rationale for use of clonidine with articaine and adrenaline for local anesthesia in pediatric dentistry

• Published in: Stomatologija (Moskva) Vol. 93; no. 3; p. 48
• Main Authors: Mel'nikova, A V, Shugaĭlov, I A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2014
• Subjects: Adaptation, Physiological - drug effects; Anesthesia, Dental - adverse effects; Anesthesia, Dental - methods; Anesthesia, Local - adverse effects; Anesthesia, Local - methods; Anesthetics, Local - administration & dosage; Cardiovascular System - drug effects; Carticaine - administration & dosage; Carticaine - adverse effects; Child; Clonidine - administration & dosage; Clonidine - adverse effects; Epinephrine - administration & dosage; Epinephrine - adverse effects; Female; Humans; Male
• ISSN: 0039-1735

The study evaluated the effect of local anesthesia with articaine in different combinations with epinephrine and clonidine (articaine (4%) + epinephrine (1:200 000), articaine (4%) + clonidine (1:100 000), articaine (4%) + epinephrine (1:200 000) + clonidine (1:100 000), articaine (4%) + epinephrine (1:400 000) + clonidine (1:100 000)), on a number of physiological parameters in pediatric dental practice that characterize cardiovascular system, patient's degree of adaptation to a stressful situation and efficacy of analgesia. It is shown that in terms of impact on the cardiovascular system and stress adaptation indicators anesthesia including combination of epinephrine (1: 200 000) and clonidine (1: 100 000) in the anesthetic solution is the safest. Furthermore, this method ensures the most appropriate analgesic effect.